RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome
- Irene Sambri, Marco Ferniani, Giulia Campostrini, …, Francesco Trepiccione, Vincenzo Nigro, Andrea Ballabio
- Nat Commun, 10.1038/s41467-023-38428-2
The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1
- Marie-Anne Deprez, Marco Caligaris, Joëlle Rosseels, …, Sabine Rospert, Claudio De Virgilio, Joris Winderickx
- PLoS Genet, 10.1371/journal.pgen.1010641
Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation
- Marco Caligaris, Raffaele Nicastro, Zehan Hu, …, Paola Coccetti, Jörn Dengjel, Claudio De Virgilio
- Elife, 10.7554/elife.84319
Manganese is a physiologically relevant TORC1 activator in yeast and mammals
- Raffaele Nicastro, Hélène Gaillard, Laura Zarzuela, …, Raúl V Durán, Claudio De Virgilio, Ralf Erik Wellinger
- Elife, 10.7554/elife.80497
The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity
- Jieqiong Gao, Raffaele Nicastro, Marie-Pierre Péli-Gulli, …, Claudio De Virgilio, Florian Fröhlich, Christian Ungermann
- J Cell Biol, 10.1083/jcb.202109084
Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast
- Ladislav Dokládal, Michael Stumpe, Zehan Hu, Malika Jaquenoud, Jörn Dengjel, Claudio De Virgilio
- Cell Rep, 10.1016/j.celrep.2021.110149
Global phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms of translational control
- Ladislav Dokládal, Michael Stumpe, Benjamin Pillet, …, Dieter Kressler, Jörn Dengjel, Claudio De Virgilio
- Mol Cell, 10.1016/j.molcel.2021.02.037
Indole-3-acetic acid is a physiological inhibitor of TORC1 in yeast
- Raffaele Nicastro, Serena Raucci, Agnès H Michel, …, Malika Jaquenoud, Benoît Kornmann, Claudio De Virgilio
- PLoS Genet, 10.1371/journal.pgen.1009414
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
- Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, …, Judith C Sluimer, Christina L Stallings, Chun-Kit Tong
- Autophagy, 10.1080/15548627.2020.1797280
Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock
- Andrea Brenna, Iwona Olejniczak, Rohit Chavan, …, Claudio De Virgilio, Jörn Dengjel, Urs Albrecht
- Elife, 10.7554/elife.50925
Multilayered Control of Protein Turnover by TORC1 and Atg1
- Zehan Hu, Serena Raucci, Malika Jaquenoud, …, Fulvio Reggiori, Claudio De Virgilio, Jörn Dengjel
- Cell Rep, 10.1016/j.celrep.2019.08.069
TORC1 specifically inhibits microautophagy through ESCRT-0
- Riko Hatakeyama, Claudio De Virgilio
- Curr Genet, 10.1007/s00294-019-00982-y
A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast
- Riko Hatakeyama, Claudio De Virgilio
- Autophagy, 10.1080/15548627.2019.1580107
Spatially distinct pools of TORC1 balance protein homeostasis
- Vikramjit Lahiri, Daniel J Klionsky
- Autophagy, 10.1080/15548627.2019.1575162