Energy substrate metabolism, mitochondrial structure and oxidative stress after cardiac ischemia-reperfusion in mice lacking UCP3
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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
- Christian G Peace, Emily A Day, Ming Yang, …, Caroline Jefferies, Christian Frezza, Luke A J O’Neill
- Nature, 10.1038/s41586-023-05720-6
Fumarate induces vesicular release of mtDNA to drive innate immunity
- Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, …, Mark Johnson, Julien Prudent, Christian Frezza
- Nature, 10.1038/s41586-023-05770-w
Primary cilia sense glutamine availability and respond via asparagine synthetase
- Maria Elena Steidl, Elisa A Nigro, Anne Kallehauge Nielsen, …, Ronald Roepman, Christian Frezza, Alessandra Boletta
- Nat Metab, 10.1038/s42255-023-00754-6
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke
- Amin Mottahedin, Hiran A Prag, Andreas Dannhorn, …, Christian Frezza, Michael P Murphy, Thomas Krieg
- Redox Biol, 10.1016/j.redox.2023.102600
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
- Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, …, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
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HIRA loss transforms FH -deficient cells
- Lorea Valcarcel-Jimenez, Connor Rogerson, Cissy Yong, …, Sakari Vanharanta, David J Adams, Christian Frezza
- Sci Adv, 10.1126/sciadv.abq8297
Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses
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