Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes
- Akira Terakawa, Yanhui Hu, Toshiya Kokaji, …, Martha L Bulyk, Norbert Perrimon, Shinya Kuroda
- None, 10.1016/j.isci.2022.104231
Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting
- Patrick Jouandin, Zvonimir Marelja, Yung-Hsin Shih, …, Christian C Dibble, Matias Simons, Norbert Perrimon
- Science, 10.1126/science.abc4203
Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells
- Andrey A Parkhitko, Arashdeep Singh, Sharon Hsieh, …, Sridhar Hannenhalli, Colm J Ryan, Norbert Perrimon
- PLoS Genet, 10.1371/journal.pgen.1009354
ARDD 2020: from aging mechanisms to interventions
- Garik V Mkrtchyan, Kotb Abdelmohsen, Pénélope Andreux, …, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen
- Aging (Albany NY), 10.18632/aging.202454
Downregulation of the tyrosine degradation pathway extends Drosophila lifespan
- Andrey A Parkhitko, Divya Ramesh, Lin Wang, …, Joshua D Rabinowitz, Axel Brockmann, Norbert Perrimon
- Elife, 10.7554/elife.58053
Targeting metabolic pathways for extension of lifespan and healthspan across multiple species
- Andrey A Parkhitko, Elizabeth Filine, Stephanie E Mohr, Alexey Moskalev, Norbert Perrimon
- Ageing Res Rev, 10.1016/j.arr.2020.101188
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
- Andrey A Parkhitko, Patrick Jouandin, Stephanie E Mohr, Norbert Perrimon
- Aging Cell, 10.1111/acel.13034
Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes
- Natalia Rodriguez-Muela, Andrey Parkhitko, Tobias Grass, …, Norbert Perrimon, Rajat Singh, Lee L Rubin
- J Clin Invest, 10.1172/jci95231
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis
- Hilaire C Lam, Christian V Baglini, Alicia Llorente Lope, …, Mustafa Sahin, Carmen Priolo, Elizabeth P Henske
- Cancer Res, 10.1158/0008-5472.can-16-2458
Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices
- Elizaveta S Leshchiner, Andrey Parkhitko, Gregory H Bird, …, Marina Godes, Norbert Perrimon, Loren D Walensky
- Proc Natl Acad Sci U S A, 10.1073/pnas.1413185112
Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload
- Usamah S Kayyali, Christopher G Larsen, Sarah Bashiruddin, …, Yvonne Chekaluk, David J Kwiatkowski, Geraldine A Finlay
- Cardiovasc Pathol, 10.1016/j.carpath.2014.10.005
High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting
- Doug Medvetz, Yang Sun, Chenggang Li, …, Soumitro Pal, Jane Yu, Elizabeth P Henske
- Mol Cancer Res, 10.1158/1541-7786.mcr-14-0440