RabLab – June 2023

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Nature metabolism

Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis.

2023-06-19

PubMed:37337122; DOI:10.1038/s42255-023-00825-8

Grace Park1, John A Haley2, Johnny Le1, Su Myung Jung3, Timothy P Fitzgibbons4, Ekaterina D Korobkina2, Huawei Li2, Shelagh M Fluharty2, Qingbo Chen2, Jessica B Spinelli2, Chinmay M Trivedi4, Cholsoon Jang5, David A Guertin6

AI-generated cartoon-styled profile picture of Cholsoon Jang

Affiliations
  1. Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA
  2. Program in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA
  3. Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea
  4. Division of Cardiovascular Medicine, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA
  5. Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
  6. Program in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA.
Cell metabolism

Acetate controls endothelial-to-mesenchymal transition.

2023-06-15

PubMed:37327791; DOI:10.1016/j.cmet.2023.05.010

Xiaolong Zhu1, Yunyun Wang2, Ioana Soaita3, Heon-Woo Lee1, Hosung Bae4, Nabil Boutagy5, Anna Bostwick6, Rong-Mo Zhang1, Caitlyn Bowman3, Yanying Xu7, Sophie Trefely8, Yu Chen2, Lingfeng Qin5, William Sessa5, George Tellides5, Cholsoon Jang4, Nathaniel W Snyder6, Luyang Yu9, Zoltan Arany10, Michael Simons11

AI-generated cartoon-styled profile picture of Cholsoon Jang

Affiliations
  1. Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
  2. MOE Laboratory of Biosystems Homeostasis & Protection of College of Life Sciences, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China
  3. Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  4. Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA
  5. Vascular Biology and Therapeutics Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
  6. Center for Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA
  7. Department of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, China
  8. Epigenetics and Signaling Program, Babraham Institute, Cambridge, UK
  9. MOE Laboratory of Biosystems Homeostasis & Protection of College of Life Sciences, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
  10. Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  11. Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Cell reports

Liver and muscle circadian clocks cooperate to support glucose tolerance in mice.

2023-06-01

PubMed:37267101; DOI:10.1016/j.celrep.2023.112588

Jacob G Smith1, Kevin B Koronowski2, Thomas Mortimer3, Tomoki Sato4, Carolina M Greco5, Paul Petrus6, Amandine Verlande7, Siwei Chen8, Muntaha Samad8, Ekaterina Deyneka8, Lavina Mathur7, Ronnie Blazev9, Jeffrey Molendijk9, Arun Kumar10, Oleg Deryagin10, Mireia Vaca-Dempere10, Valentina Sica10, Peng Liu11, Valerio Orlando11, Benjamin L Parker9, Pierre Baldi8, Patrick-Simon Welz12, Cholsoon Jang7, Selma Masri7, Salvador Aznar Benitah13, Pura Muñoz-Cánoves14, Paolo Sassone-Corsi15

AI-generated cartoon-styled profile picture of Cholsoon Jang

Affiliations
  1. Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.
  2. Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
  3. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
  4. Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
  5. Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy
  6. Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Medicine (H7), Karolinska Institutet, 141 86 Stockholm, Sweden
  7. Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA
  8. Institute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA
  9. Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia
  10. Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain
  11. King Abdullah University of Science and Technology, KAUST Environmental Epigenetics Research Program, Biological and Environmental Sciences and Engineering Division, Thuwal 23955, Saudi Arabia
  12. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Program in Cancer Research, Hospital del Mar Medical Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain
  13. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.
  14. Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA 92121, USA.
  15. Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA
Cell metabolism

Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood.

2023-06-01

PubMed:37267956; DOI:10.1016/j.cmet.2023.05.002

Lin Lin1, Kwang-Mook Jung1, Hye-Lim Lee1, Johnny Le2, Georgia Colleluori3, Courtney Wood4, Francesca Palese1, Erica Squire1, Jade Ramirez1, Shiqi Su1, Alexa Torrens1, Yannick Fotio1, Lingyi Tang5, Clinton Yu5, Qin Yang5, Lan Huang5, Nicholas DiPatrizio4, Cholsoon Jang2, Saverio Cinti3, Daniele Piomelli6

AI-generated cartoon-styled profile picture of Cholsoon Jang

Affiliations
  1. Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA
  2. Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA
  3. Department of Clinical and Experimental Medicine, Center of Obesity, Marche Polytechnic University, Ancona 600126, Italy
  4. Department of Biomedical Sciences, University of California, Riverside, Riverside, CA 92697, USA
  5. Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA
  6. Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA.
bioRxiv

The Genetics of Aerotolerant Growth in a Naturally Reduced Genome Alphaproteobacterium

2023-06-13

DOI:10.1101/2023.06.12.544693

A. L. Enright, A. B. Banta, R. D. Ward, J. Rivera Vazquez, M. M. Felczak, M. B. Wolfe, M. A. TerAvest, D. Amador-Noguez, J. M. Peters

AI-generated cartoon-styled profile picture of Daniel Amador-Noguez

Affiliations
  1. University of Wisconsin-Madison

cancer-and-disease

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Neuro-oncology

PKM2 rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance.

2023-06-05

PubMed:37279645; DOI:10.1093/neuonc/noad103

Justine Bailleul1, Yangjingyi Ruan1, Lobna Abdulrahman1, Andrew J Scott2, Taha Yazal1, David Sung1, Keunseok Park3, Hanna Hoang1, Juan Nathaniel1, Fang-I Chu1, Daisy Palomera1, Anahita Sehgal1, Jonathan E Tsang4, David A Nathanson4, Shili Xu5, Junyoung O Park3, Johanna Ten Hoeve4, Kruttika Bhat1, Nathan Qi6, Harley I Kornblum5, Dorthe Schaue1, William H McBride1, Costas A Lyssiotis6, Daniel R Wahl2, Erina Vlashi1

Affiliations
  1. Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA
  2. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI
  3. Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA
  4. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA
  5. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA
  6. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI
Molecular metabolism

Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration.

2023-06-07

PubMed:37295745; DOI:10.1016/j.molmet.2023.101751

Melissa A Linden1, Susan J Burke2, Humza A Pirzadah3, Tai-Yu Huang4, Heidi M Batdorf5, Walid K Mohammed6, Katarina A Jones7, Sujoy Ghosh8, Shawn R Campagna9, J Jason Collier10, Robert C Noland11

Affiliations
  1. Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA; Department of Exercise and Health Sciences, University of Massachusetts-Boston, Boston, MA, 02125, USA.
  2. Laboratory of Immunogenetics, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
  3. Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
  4. Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
  5. Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
  6. Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
  7. Biological and Small Molecule Mass Spectrometry Core, University of Tennessee, Knoxville, TN, 37916, USA.
  8. Laboratory of Computational Biology, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA; Program in Cardiovascular and Metabolic Disorders and Center for Computational Biology, Duke-National University of Singapore Medical School, Singapore, 169857, Singapore.
  9. Biological and Small Molecule Mass Spectrometry Core, University of Tennessee, Knoxville, TN, 37916, USA.
  10. Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
  11. Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
European journal of pharmacology

Metabolic rewiring and epigenetic reprogramming in leptin receptor-deficient db/db diabetic nephropathy mice.

2023-06-16

PubMed:37331680; DOI:10.1016/j.ejphar.2023.175866

Md Shahid Sarwar1, David Cheng2, Rebecca Mary Peter2, Ahmad Shannar2, Pochung Chou2, Lujing Wang2, Renyi Wu1, Davit Sargsyan2, Michael Goedken3, Yujue Wang4, Xiaoyang Su4, Ronald P Hart5, Ah-Ng Kong6

Affiliations
  1. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA
  2. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA; Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA
  3. Office of Translational Science, Research Pathology Services, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA
  4. Metabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08901, USA
  5. Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA
  6. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.

career

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Cell

Juneteenth in STEMM and the barriers to equitable science.

2023-06-08

PubMed:37295396; DOI:10.1016/j.cell.2023.05.016

Alfred Mays1, Angela Byars-Winston2, Antentor Hinton3, Andrea G Marshall4, Annet Kirabo5, Avery August6, Bianca J Marlin7, Blake Riggs8, Blanton Tolbert9, Celestine Wanjalla10, Chad Womack11, Chantell S Evans12, Christopher Barnes13, Chrystal Starbird14, Clintoria Williams15, Corey Reynolds16, Cornelius Taabazuing17, Craig E Cameron18, Debra D Murray19, Derek Applewhite20, Derrick J Morton21, Dexter Lee22, Dionna W Williams23, Donald Lynch24, Donita Brady25, Erin Lynch26, Florentine U N Rutaganira27, Gustavo M Silva28, Haysetta Shuler29, Ishmail Abdus Saboor30, Jamaine Davis31, Kafui Dzirasa32, Latanya Hammonds-Odie33, Loretta Reyes34, Mariya T Sweetwyne35, Melanie R McReynolds36, Michael D L Johnson37, Nathan A Smith38, Nikea Pittman14, Olujimi A Ajijola39, Quinton Smith40, Renã A S Robinson41, Samantha C Lewis42, Sandra A Murray43, Sherilynn Black44, Sonya E Neal45, Stanley Andrisse46, Steven Townsend41, Steven M Damo47, Theanne N Griffith48, W Marcus Lambert49, William M Clemons50

AI-generated cartoon-styled profile picture of Melanie R McReynolds

Affiliations
  1. Burroughs Wellcome Fund, Durham, NC 27709, USA
  2. Department of Medicine, Institute for Diversity Science, University of Wisconsin-Madison, Madison, WI 53715, USA
  3. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
  4. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA
  5. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA; Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA
  6. Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
  7. Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Psychology, Columbia University, New York, NY 10032, USA; Department of Neuroscience, Columbia University, New York, NY 10027, USA
  8. Department of Biology, San Francisco State University, San Francisco, CA 94132, USA
  9. Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
  10. Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA
  11. National STEM Programs and Tech Initiatives at the education philanthropic charity, UNCF, Washington, DC 20001, USA
  12. Department of Cell Biology, Duke University Medical Center, Durham, NC 27708, USA
  13. Department of Biology, Stanford University, Stanford, CA 94305, USA
  14. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
  15. Department of Neuroscience, Cell Biology & Physiology, College of Science and Mathematics, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, USA
  16. Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA; Mouse Phenotyping Core, Baylor College of Medicine, Houston, TX 77030, USA
  17. Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
  18. Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
  19. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
  20. Department of Biology, Reed College, Portland, OR 97202, USA
  21. Department of Biological Sciences, University of Southern California Los Angeles, Los Angeles, CA 90089, USA
  22. Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA
  23. Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
  24. Department of Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, OH, USA
  25. Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  26. University of Michigan Health System, Ann Arbor, MI 48109, USA
  27. Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
  28. Department of Biology, Duke University, Durham, NC 27708, USA
  29. Winston-Salem State University Department of Biological Sciences, Winston-Salem, NC 27110, USA
  30. Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
  31. Department of Biochemistry, Cancer Biology, Neuroscience, Pharmacology, Meharry Medical College, Nashville, TN 37232, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA
  32. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
  33. Department of Biological Sciences before School of Science and Technology, Georgia Gwinnett College, Lawrenceville, GA 30043, USA
  34. Division of Pediatric Nephrology, Emory University School of Medicine, Atlanta, GA 30322, USA
  35. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA
  36. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
  37. Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA; BIO5 Institute, University of Arizona, Tucson, AZ 85724, USA; Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA
  38. Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
  39. UCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
  40. School of Engineering, University of California, Irvine, CA 92697-3975, USA
  41. Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA
  42. Department of Molecular and Cellular Biology, University of California Berkeley, Berkeley, CA 94720, USA
  43. Department of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 52013, USA.
  44. Office of the Provost and Division of Medical Education, Duke University, Durham, NC 27708, USA.
  45. Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
  46. Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA; Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
  47. Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA; Department of Life and Physical Sciences, Fisk University, Nashville, TN 37208, USA.
  48. Department of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616, USA
  49. Department of Epidemiology and Biostatistics, SUNY Downstate Health Sciences University, New York, NY 11203, USA
  50. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA

human-health

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Transportation research. Part C, Emerging technologies

A distributionally robust optimization approach for airline integrated recovery under in-flight pandemic transmission risks.

2023-06-07

PubMed:37305559; DOI:10.1016/j.trc.2023.104188

Yifan Xu1, Sebastian Wandelt1, Xiaoqian Sun1

Affiliations
  1. School of Electronic and Information Engineering, Beihang University, 100191, Beijing, China

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