The intracellular degradation of protein may be achieved in a ubiquitin-dependent process that targets unwanted proteins to proteasome. Wikipedia (CC BY-SA 3.0)
2023 Articles
16 708 articles
Retraction Note: Targeting KDM4A-AS1 represses AR/AR-Vs deubiquitination and enhances enzalutamide response in CRPC
- Boya Zhang, Mingpeng Zhang, Yanjie Yang, …, Shimiao Zhu, Yuanjie Niu, Zhiqun Shang
- Oncogene, 10.1038/s41388-023-02790-8
A chemical strategy to study transient states in substrate ubiquitylation by cryo-EM
- Qi Hu, Maria Victoria Botuyan, Georges Mer, Qi Hu, Maria Victoria Botuyan, Georges Mer
- None, 10.1016/j.chempr.2023.04.016
Life mimics art
- Muthukumaran Venkatachalapathy, Craig M Crews, Muthukumaran Venkatachalapathy, …, Craig M Crews, Muthukumaran Venkatachalapathy, Craig M Crews
- Cell Res, 10.1038/s41422-022-00765-0
Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradation
- Roland Hjerpe, Thimo Kurz, Roland Hjerpe, …, Thimo Kurz, Roland Hjerpe, Thimo Kurz
- Mol Cell, 10.1016/j.molcel.2023.06.017
The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48
- Cameron Williams, Ken C Dong, Connor Arkinson, …, Ken C Dong, Connor Arkinson, Andreas Martin
- Mol Cell, 10.1016/j.molcel.2023.01.016
CELMoD for ALL: an exciting prospect
- Takahiro Maeda, Takahiro Maeda, Takahiro Maeda
- Blood, 10.1182/blood.2023020923
An engineered cell line with a hRpn1-attached handle to isolate proteasomes
- Hitendra Negi, Vasty Osei-Amponsa, Bishoy Ibrahim, …, Jadranka Loncarek, Raj Chari, Kylie J Walters
- J Biol Chem, 10.1016/j.jbc.2023.104948
Targeted Protein Degradation through E2 Recruitment
- Nafsika Forte, Dustin Dovala, Matthew J Hesse, …, John A Tallarico, Markus Schirle, Daniel K Nomura
- ACS Chem Biol, 10.1021/acschembio.3c00040
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance
- Alexander Hanzl, Eleonora Barone, Sophie Bauer, …, Stefan Kubicek, Eric S Fischer, Georg E Winter
- J Am Chem Soc, 10.1021/jacs.2c10784
Assembly and disassembly of branched ubiquitin chains
- Justin B Gregor, Dantong Xu, Michael E French, …, Justin B Gregor, Dantong Xu, Michael E French
- None, 10.3389/fmolb.2023.1197272
2022 Articles
1 683 articles
Design, synthesis and biological evaluation of novel quinazolinone derivatives as CRBN E3 ligase modulators
- Linyi Liu, Renhong Sun, Haixia Liu, …, Ying Kong, Biao Jiang, Xiaobao Yang
- Eur J Med Chem, 10.1016/j.ejmech.2022.115016
CIDE-stepping E3s
- Gary Tin, Gary Tin, Gary Tin, Georg E Winter, Gary Tin, Georg E Winter
- Nat Chem Biol, 10.1038/s41589-022-01217-x
Ubiquitin modulates 26S proteasome conformational dynamics and promotes substrate degradation
- Erik Jonsson, Zaw Min Htet, Jared A M Bard, …, Jared A M Bard, Ken C Dong, Andreas Martin
- Sci Adv, 10.1126/sciadv.add9520
Current Challenges in Small Molecule Proximity-Inducing Compound Development for Targeted Protein Degradation Using the Ubiquitin Proteasomal System
- Sridhar Radhakrishnan, Oskar Hoff, Markus K Muellner, …, Sridhar Radhakrishnan, Oskar Hoff, Markus K Muellner
- Molecules, 10.3390/molecules27238119
SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF
- Kai Feng, Qing Shi, Dongyue Jiao, …, Pingzhao Zhang, Yao Li, Chenji Wang
- None, 10.1186/s13578-022-00950-z
Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix
- Li Zhou, In Ho Jeong, Songyi Xue, …, Jianfeng Cai, Jun Yin, Bo Huang
- J Med Chem, 10.1021/acs.jmedchem.2c01459
Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins
- Ashley P Viera Ortiz, Gregory Cajka, Olamide A Olatunji, …, Bailey Mikytuck, Ophir Shalem, Edward B Lee
- Brain, 10.1093/brain/awac479
Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras
- Thang Cong Do, Jun Wei Lau, Caixia Sun, …, Thomas James Carney, Xiaomeng Wang, Bengang Xing
- Sci Adv, 10.1126/sciadv.abq2216
CHIP: A Co-chaperone for Degradation by the Proteasome and Lysosome
- Abantika Chakraborty, Adrienne L Edkins, Abantika Chakraborty, …, Adrienne L Edkins, Abantika Chakraborty, Adrienne L Edkins
- Subcell Biochem, 10.1007/978-3-031-14740-1_12
Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA
- Gus D Warren, Tomoe Kitao, Tyler G Franklin, …, Tomoko Kubori, Hiroki Nagai, Jonathan N Pruneda
- Mol Cell, 10.1016/j.molcel.2022.11.022