Transcriptome engineering refers to the manipulation of the transcriptome, which encompasses all RNA molecules expressed from genes in a cell. By altering the transcriptome, scientists can influence gene expression patterns, leading to changes in cellular phenotype, function, and behavior. ChatGPT (CC BY 4.0)
2023 Articles
4 046 articles
Dynamical model fitting to a synthetic positive feedback circuit in E. coli
- Jure Tica, Tong Zhu, Mark Isalan, Jure Tica, Tong Zhu, Mark Isalan
- None, 10.1049/enb.2020.0009
Growth Feedback Confers Cooperativity in Resource-Competing Synthetic Gene Circuits
- Juan Ramon Melendez-Alvarez, Rong Zhang, Xiao-Jun Tian, Juan Ramon Melendez-Alvarez, Rong Zhang, Xiao-Jun Tian
- None, 10.1016/j.chaos.2023.113713
Context-Aware Technology Mapping in Genetic Design Automation
- Nicolai Engelmann, Tobias Schwarz, Erik Kubaczka, …, Erik Kubaczka, Christian Hochberger, Heinz Koeppl
- ACS Synth Biol, 10.1021/acssynbio.2c00361
Development of Terminator-Promoter Bifunctional Elements for Application in Saccharomyces cerevisiae Pathway Engineering
- Xiaoxia Ni, Zhengyang Liu, Jintang Guo, …, Zhengyang Liu, Jintang Guo, Genlin Zhang
- Int J Mol Sci, 10.3390/ijms24129870
Taming CRISPRi: Dynamic range tuning through guide RNA diversion
- Bob Van Hove, Lien De Wannemaeker, Isolde Missiaen, …, Isolde Missiaen, Jo Maertens, Marjan De Mey
- N Biotechnol, 10.1016/j.nbt.2023.07.001
Model-driven experimental design workflow expands understanding of regulatory role of Nac in Escherichia coli
- Joon Young Park, Sang-Mok Lee, Ali Ebrahim, …, Sang Woo Seo, Bernhard O Palsson, Donghyuk Kim
- None, 10.1093/nargab/lqad006
A portable regulatory RNA array design enables tunable and complex regulation across diverse bacteria
- Baiyang Liu, Christian Cuba Samaniego, Matthew R Bennett, …, Matthew R Bennett, Elisa Franco, James Chappell
- Nat Commun, 10.1038/s41467-023-40785-x
A portable regulatory RNA array design enables tunable and complex regulation across diverse bacteria
- Baiyang Liu, Christian Cuba Samaniego, Matthew R Bennett, …, Matthew R Bennett, Elisa Franco, James Chappell
- bioRxiv : the preprint server for biology, 10.1101/2023.02.24.529951
Reducing metabolic burden in the PACEmid evolver system by remastering high-copy phagemid vectors
- Beth India Davenport, Jure Tica, Mark Isalan, Beth India Davenport, Jure Tica, Mark Isalan
- None, 10.1049/enb2.12021
Bayesian filtering for model predictive control of stochastic gene expression in single cells
- Zachary Fox, Gregory Batt, Jakob Ruess, …, Zachary R Fox, Gregory Batt, Jakob Ruess
- Phys Biol, 10.1088/1478-3975/ace094
2022 Articles
360 articles
De novo design of the global transcriptional factor Cra-regulated promoters enables highly sensitive glycolysis flux biosensor for dynamic metabolic control
- Yuan Zhu, Huaxiao Gao, Jian Zhang, …, Jingyu Zhao, Qingsheng Qi, Qian Wang
- Microb Biotechnol, 10.1111/1751-7915.14166
Functional Resilience of Mutually Repressing Motifs Embedded in Larger Networks
- Pradyumna Harlapur, Atchuta Srinivas Duddu, Kishore Hari, …, Kishore Hari, Prakash Kulkarni, Mohit Kumar Jolly
- Biomolecules, 10.3390/biom12121842
Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer
- Yang Joon Kim, Kaitlin Rhee, Jonathan Liu, …, Meghan A Turner, Stephen J Small, Hernan G Garcia
- Elife, 10.7554/elife.73395
Dynamic feedback regulation for efficient membrane protein production using a small RNA-based genetic circuit in Escherichia coli
- Chiara Guidi, Lien De Wannemaeker, Jasmine De Baets, …, Jo Maertens, Brecht De Paepe, Marjan De Mey
- Microb Cell Fact, 10.1186/s12934-022-01983-2
Tuning the Transcriptional Activity of the CaMV 35S Promoter in Plants by Single-Nucleotide Changes in the TATA Box
- Stephanie C Amack, Savio S Ferreira, Mauricio S Antunes, …, Stephanie C Amack, Savio S Ferreira, Mauricio S Antunes
- ACS Synth Biol, 10.1021/acssynbio.2c00457
Logic Circuits Based on 2A Peptide Sequences in the Yeast Saccharomyces cerevisiae
- Xuekun Wang, Ximing Tian, Mario Andrea Marchisio, …, Xuekun Wang, Ximing Tian, Mario Andrea Marchisio
- ACS Synth Biol, 10.1021/acssynbio.2c00506
Accuracy and data efficiency in deep learning models of protein expression
- Evangelos-Marios Nikolados, Arin Wongprommoon, Oisin Mac Aodha, …, Oisin Mac Aodha, Guillaume Cambray, Diego A Oyarzún
- Nat Commun, 10.1038/s41467-022-34902-5
Engineering Pheromone-Mediated Quorum Sensing with Enhanced Response Output Increases Fucosyllactose Production in Saccharomyces cerevisiae
- Mingyuan Xu, Mengtong Sun, Xiangfeng Meng, …, Weixin Zhang, Yu Shen, Weifeng Liu
- ACS Synth Biol, 10.1021/acssynbio.2c00507
Genome-wide inference reveals that feedback regulations constrain promoter-dependent transcriptional burst kinetics
- Songhao Luo, Zihao Wang, Zhenquan Zhang, …, Zhenquan Zhang, Tianshou Zhou, Jiajun Zhang
- Nucleic Acids Res, 10.1093/nar/gkac1204
Developing Cyanobacterial Quorum Sensing Toolkits: Toward Interspecies Coordination in Mixed Autotroph/Heterotroph Communities
- Emmanuel J Kokarakis, Rees Rillema, Daniel C Ducat, …, Rees Rillema, Daniel C Ducat, Jonathan K Sakkos
- ACS Synth Biol, 10.1021/acssynbio.2c00527