In humans, melatonin is a full agonist of melatonin receptor 1 (picomolar binding affinity) and melatonin receptor 2 (nanomolar binding affinity), both of which belong to the class of G-protein coupled receptors (GPCRs). Melatonin receptors 1 and 2 are both Gi/o-coupled GPCRs, although melatonin receptor 1 is also Gq-coupled. Melatonin also acts as a high-capacity free radical scavenger within mitochondria which also promotes the expression of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase via signal transduction through melatonin receptors. Wikipedia (CC BY-SA 3.0)
2023 Articles
1 620 articles
Circadian misalignment increases 24-hour acylated ghrelin in chronic shift workers: a randomized crossover trial
- Jingyi Qian, Christopher J Morris, Rosanna Caputo, …, Christopher J Morris, Rosanna Caputo, Frank A J L Scheer
- Obesity (Silver Spring), 10.1002/oby.23838
Circadian Interventions as Adjunctive Therapies to Cognitive-Behavioral Therapy for Insomnia
- Leslie M Swanson, Greta B Raglan, Leslie M Swanson, …, Greta B Raglan, Leslie M Swanson, Greta B Raglan
- Sleep Med Clin, 10.1016/j.jsmc.2022.09.004
The dim light melatonin onset across ages, methodologies, and sex and its relationship with morningness/eveningness
- David J Kennaway, David J Kennaway, David J Kennaway, David J Kennaway, David J Kennaway
- Sleep, 10.1093/sleep/zsad033
Heart failure causes sleepless nights
- Harvey Davis, David Attwell, Harvey Davis, David Attwell, Harvey Davis, David Attwell
- Science, 10.1126/science.adj0217
Age-related changes in circadian regulation of the human plasma lipidome
- Shadab A Rahman, Rose M Gathungu, Vasant R Marur, …, Elizabeth B Klerman, Jeanne F Duffy, Bruce S Kristal
- Commun Biol, 10.1038/s42003-023-05102-8
Clock 3111 T/C and Period3 VNTR gene polymorphisms and proteins, and melatonin levels in women with infertility
- Gulay Ciftci, Serbulent Yigit, Ozlem Sezer, …, Serbulent Yigit, Ozlem Sezer, Adem Keskin
- J Assist Reprod Genet, 10.1007/s10815-023-02756-5
Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies
- Maria Mentzelou, Sousana K Papadopoulou, Dimitrios Papandreou, …, Eleni Pavlidou, Maria Mantzorou, Constantinos Giaginis
- None, 10.3390/metabo13030370
In the Light: Towards Developing Metrics of Light Regularity
- Danielle A Wallace, Danielle A Wallace, Danielle A Wallace, Danielle A Wallace, Danielle A Wallace
- Sleep, 10.1093/sleep/zsad114
The Mammalian Circadian Time-Keeping System
- Andrew P Patton, Michael H Hastings, Andrew P Patton, …, Michael H Hastings, Andrew P Patton, Michael H Hastings
- J Huntingtons Dis, 10.3233/jhd-230571
Updates and confounding factors in delayed sleep-wake phase disorder
- Alexandra Wu, Alexandra Wu
- None, 10.1007/s41105-023-00454-4
2022 Articles
193 articles
A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study
- Raphaëlle Glacet, Eve Reynaud, Ludivine Robin-Choteau, …, Ãœlker Kilic-Huck, Henri Comtet, Patrice Bourgin
- Chronobiol Int, 10.1080/07420528.2022.2150554
Keeping an eye on circadian time in clinical research and medicine
- Elizabeth B Klerman, Allison Brager, Mary A Carskadon, …, Steffen Tiedt, Phyllis C Zee, Helen J Burgess
- Clin Transl Med, 10.1002/ctm2.1131
Melatonin immunoreactivity of epidermal skin is higher in the evening than morning but does not account for erythema sensitivity
- Veera Nikkola, Riitta Huotari-Orava, Heli Joronen, …, Lasse Ylianttila, Erna Snellman, Timo Partonen
- Chronobiol Int, 10.1080/07420528.2022.2157733
Circadian phase advances in children during camping life according to the natural light-dark cycle
- Taisuke Eto, Shingo Kitamura, Kana Nishimura, …, Akiko Shikano, Shingo Noi, Shigekazu Higuchi
- J Physiol Anthropol, 10.1186/s40101-022-00316-x
Genome-wide gene by environment study of time spent in daylight and chronotype identifies emerging genetic architecture underlying light sensitivity
- Angus C Burns, Andrew J K Phillips, Martin K Rutter, …, Richa Saxena, Sean W Cain, Jacqueline M Lane
- Sleep, 10.1093/sleep/zsac287
Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot study
- Soyhan Bagci, Astrid Wieduwilt, Ebru Aileen Alsat, …, Herbert Plischke, Tamene Melaku, Andreas Müller
- Front Endocrinol (Lausanne), 10.3389/fendo.2022.1043366
Circadian rhythms and the liver
- Rodolfo Costa, Chiara Mangini, Esther Domenie, …, Esther D Domenie, Lisa Zarantonello, Sara Montagnese
- Liver Int, 10.1111/liv.15501
Circadian medicine for aging attenuation and sleep disorders: Prospects and challenges
- Srishti Banerjee, Sandipan Ray, Srishti Banerjee, …, Sandipan Ray, Srishti Banerjee, Sandipan Ray
- Prog Neurobiol, 10.1016/j.pneurobio.2022.102387
Understanding light pollution: Recent advances on its health threats and regulations
- Miao Cao, Ting Xu, Daqiang Yin, Miao Cao, Ting Xu, Daqiang Yin
- J Environ Sci (China), 10.1016/j.jes.2022.06.020
From Bench to Bedside and Back Again: Translating Circadian Science to Medicine
- Elizabeth B Klerman, Achim Kramer, Phyllis C Zee, …, Elizabeth B Klerman, Achim Kramer, Phyllis C Zee
- J Biol Rhythms, 10.1177/07487304221142743