Channel: Protein glycosylation

Glycosylation is the reaction in which a carbohydrate (or 'glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in order to form a glycoconjugate. In biology (but not always in chemistry), glycosylation usually refers to an enzyme-catalysed reaction, whereas glycation (also 'non-enzymatic glycation' and 'non-enzymatic glycosylation') may refer to a non-enzymatic reaction. Wikipedia (CC BY-SA 3.0)

2023 Articles

19 375 articles

Genomic surveillance of SARS-CoV-2 upsurge in India due to Omicron sub-lineages BA.2.74, BA.2.75 and BA.2.76

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The road to death: Caspases, cleavage, and pores

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In planta expression of active bacterial GDP-6-deoxy-d-lyxo-4-hexulose reductase for glycan modulation

  • Benjamin Kogelmann, Roman Palt, Daniel Maresch, …, Pooja Saxena, Johannes S Gach, Herta Steinkellner
  • Plant Biotechnol J, 10.1111/pbi.14131
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High-throughput saturation mutagenesis generates a high-affinity antibody against SARS-CoV-2 variants using protein surface display assay on a human cell

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Expression and Characterisation of the First Snail-Derived UDP-Gal: Glycoprotein-N-acetylgalactosamine β-1,3-Galactosyltransferase (T-Synthase) from Biomphalaria glabrata

  • Marilica Zemkollari, Markus Blaukopf, Reingard Grabherr, …, Markus Blaukopf, Reingard Grabherr, Erika Staudacher
  • Molecules, 10.3390/molecules28020552
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In vivo deglycosylation of recombinant glycoproteins in tobacco BY-2 cells

  • Xavier Herman, Johann Far, Marie Peeters, …, Loïc Quinton, François Chaumont, Catherine Navarre
  • Plant Biotechnol J, 10.1111/pbi.14074
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Enhanced antibody-defucosylation capability of α-L-fucosidase by proximity-based protein fusion

  • Shuquan Fan, Wanzhen Li, Kuixing Zhang, …, Caihong Tang, Wei Huang, Feng Tang
  • Biochem Biophys Res Commun, 10.1016/j.bbrc.2023.01.031
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Uncovering the Role of N-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry

  • Tarick J El-Baba, Corinne A Lutomski, Sean A Burnap, …, Andrew J Baldwin, Weston B Struwe, Carol V Robinson
  • J Am Chem Soc, 10.1021/jacs.3c00291
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SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor

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2022 Articles

2 034 articles

Spike protein receptor-binding domains from SARS-CoV-2 variants of interest bind human ACE2 more tightly than the prototype spike protein

  • Jermilia Charles, Nathan McCann, Victoria A Ploplis, …, Nathan McCann, Victoria A Ploplis, Francis J Castellino
  • Biochem Biophys Res Commun, 10.1016/j.bbrc.2022.12.011
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Myomedin replicas of gp120 V3 loop glycan epitopes recognized by PGT121 and PGT126 antibodies as non-cognate antigens for stimulation of HIV-1 broadly neutralizing antibodies

  • Veronika Daniel LiÅ¡ková, Petr Kosztyu, Milan KuchaÅ™, …, Leona RaÅ¡ková Kafková, Milan RaÅ¡ka, Petr Malý
  • Front Immunol, 10.3389/fimmu.2022.1066361
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Vector design for enhancing expression level and assembly of knob-into-hole based FabscFv-Fc bispecific antibodies in CHO cells

  • Han Kee Ong, Ngan T B Nguyen, Jiawu Bi, …, Ngan T B Nguyen, Jiawu Bi, Yuansheng Yang
  • None, 10.1093/abt/tbac025
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An Escherichia coli Expressed Multi-Disulfide Bonded SARS-CoV-2 RBD Shows Native-like Biophysical Properties and Elicits Neutralizing Antisera in a Mouse Model

  • Subbaian Brindha, Takahiro Yoshizue, Rawiwan Wongnak, …, Mami Oba, Tetsuya Mizutani, Yutaka Kuroda
  • Int J Mol Sci, 10.3390/ijms232415744
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A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production

  • Xiaotian Zhong, Aaron M D’Antona, Xiaotian Zhong, Aaron M D’Antona, Xiaotian Zhong, Aaron M D’Antona
  • Front Immunol, 10.3389/fimmu.2022.1072702
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A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75

  • Jiandong Huo, Aiste Dijokaite-Guraliuc, Chang Liu, …, Jingshan Ren, David I Stuart, Gavin R Screaton
  • Cell Rep, 10.1016/j.celrep.2022.111903
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Glyco-binding domain chimeric antigen receptors as a new option for cancer immunotherapy

  • Charlotte Wessolowski, Vanessa Thaden, Ingo Müller, …, Vanessa Thaden, Ingo Müller, Kerstin Cornils
  • Gene Ther, 10.1038/s41434-022-00374-x
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Indirect Mechanisms of HIV-1 Evasion from Broadly Neutralizing Antibodies In Vivo

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IgE binding epitope mapping with TL1A tagged peptides

  • Yuzhu Zhang, Shilpa R Bhardwaj, Ana Vilches, …, Sharon Chinthrajah, Kari C Nadeau, Tengchuan Jin
  • Mol Immunol, 10.1016/j.molimm.2022.12.001
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Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective

  • Debajit Dey, Zaved Hazarika, Debajit Dey, …, Subhomoi Borkotoky, Debajit Dey, Zaved Hazarika
  • Mol Biol Rep, 10.1007/s11033-022-08193-4
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