Promoters and enhancers are two essential DNA regulatory elements that play crucial roles in controlling gene expression. They work in concert to ensure that genes are turned on or off in the right cells, at the right time, and in response to specific signals. Understanding their functions and interplay is fundamental to the field of genetics and molecular biology. ChatGPT (CC BY 4.0)
2023 Articles
677 articles
Enhancer RNAs in transcriptional regulation: recent insights
- Qi Chen, Yaxin Zeng, Jinjin Kang, …, Nianle Li, Kun Sun, Yu Zhao
- None, 10.3389/fcell.2023.1205540
RNA Polymerase II, the BAF remodeler and transcription factors synergize to evict nucleosomes
- Sandipan Brahma, Steven Henikoff, Sandipan Brahma, Steven Henikoff
- bioRxiv : the preprint server for biology, 10.1101/2023.01.22.525083
Structural perspectives on transcription in chromatin
- Shun-Ichi Sekine, Haruhiko Ehara, Tomoya Kujirai, Hitoshi Kurumizaka
- Trends Cell Biol, 10.1016/j.tcb.2023.07.011
Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription
- Chun-Yi Cho, Chun-Yi Cho, Chun-Yi Cho, …, Patrick H O’Farrell, Chun-Yi Cho, Patrick H O’Farrell
- Nat Commun, 10.1038/s41467-023-40485-6
Transcriptional kinetic synergy: A complex landscape revealed by integrating modeling and synthetic biology
- Rosa Martinez-Corral, Minhee Park, Kelly M Biette, …, Ahmad S Khalil, Jeremy Gunawardena, Angela H DePace
- Cell Syst, 10.1016/j.cels.2023.02.003
High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription
- Annkatrin Bressin, Olga Jasnovidova, Mirjam Arnold, …, Joanna E Handzlik, Denes Hnisz, Andreas Mayer
- Nat Commun, 10.1038/s41467-023-40633-y
Deciphering the multi-scale, quantitative cis-regulatory code
- Seungsoo Kim, Joanna Wysocka, Seungsoo Kim, …, Joanna Wysocka, Seungsoo Kim, Joanna Wysocka
- Mol Cell, 10.1016/j.molcel.2022.12.032
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators
- Sohail Malik, Robert G Roeder
- Nat Rev Genet, 10.1038/s41576-023-00630-9
Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting
- Ineke Brouwer, Emma Kerklingh, Fred van Leeuwen, …, Emma Kerklingh, Fred van Leeuwen, Tineke L Lenstra
- Nat Struct Mol Biol, 10.1038/s41594-023-00981-1
Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation
- Atsushi Inose-Maruyama, Shuya Kasai, Ken Itoh, …, Atsushi Inose-Maruyama, Shuya Kasai, Ken Itoh
- Methods Mol Biol, 10.1007/978-1-0716-3084-6_11
2022 Articles
52 articles
Structural insights into p300 regulation and acetylation-dependent genome organisation
- Ziad Ibrahim, Tao Wang, Olivier Destaing, …, Martin Blackledge, Saadi Khochbin, Daniel Panne
- Nat Commun, 10.1038/s41467-022-35375-2
Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes reduces chromatin accessibility at promoters
- Mirna Barsoum, Alexander T Stenzel, Agnieszka Bochyńska, …, Juliane Lüscher-Firzlaff, Ivan G Costa, Bernhard Lüscher
- Sci Rep, 10.1038/s41598-022-25881-0
Impact of Saccharomyces cerevisiae on the Field of Single-Molecule Biophysics
- David A Ball, Binta Jalloh, Tatiana S Karpova, …, David A Ball, Binta Jalloh, Tatiana S Karpova
- Int J Mol Sci, 10.3390/ijms232415895
EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release
- Kaustav Mukherjee, James J Bieker, Kaustav Mukherjee, …, James J Bieker, Kaustav Mukherjee, James J Bieker
- Cell Rep, 10.1016/j.celrep.2022.111830
Chromatin modules and their implication in genomic organization and gene regulation
- Guido van Mierlo, Olga Pushkarev, Judith F Kribelbauer, …, Olga Pushkarev, Judith F Kribelbauer, Bart Deplancke
- Trends Genet, 10.1016/j.tig.2022.11.003
Novel biological insights revealed from the investigation of multiscale genome architecture
- Tianyi Ding, He Zhang, Tianyi Ding, He Zhang
- None, 10.1016/j.csbj.2022.12.009
Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer
- Yang Joon Kim, Kaitlin Rhee, Jonathan Liu, …, Meghan A Turner, Stephen J Small, Hernan G Garcia
- Elife, 10.7554/elife.73395
TALE transcription factors: Cofactors no more
- Nicoletta Bobola, Charles G Sagerström, Nicoletta Bobola, Charles G Sagerström, Nicoletta Bobola, Charles G Sagerström
- Semin Cell Dev Biol, 10.1016/j.semcdb.2022.11.015
Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation
- Kenichiro Abe, Tamas Schauer, Maria-Elena Torres-Padilla, …, Kenichiro Abe, Tamas Schauer, Maria-Elena Torres-Padilla
- Cell Rep, 10.1016/j.celrep.2022.111865
Homeodomain complex formation and biomolecular condensates in Hox gene regulation
- Joseph Salomone, Edward Farrow, Brian Gebelein, …, Joseph Salomone, Edward Farrow, Brian Gebelein
- Semin Cell Dev Biol, 10.1016/j.semcdb.2022.11.016