Inspired by: D Allan Drummond
In biochemistry, biomolecular condensates are a class of membrane-less organelles and organelle subdomains, which carry out specialized functions within the cell. Unlike many organelles, biomolecular condensate composition is not controlled by a bounding membrane. Instead, condensates can form and maintain organization through a range of different processes, the most well-known of which is phase separation of proteins, RNA and other biopolymers into either colloidal emulsions, gels, liquid crystals, solid crystals or aggregates within cells. Wikipedia (CC BY-SA 3.0)
2023 Articles
445 articles
Structure Reveals the Impact of Surface Charge Distribution on the Phase Separation and Aggregation of Slr0280
- Xiao-Dan Li, Zi-Zhu Tan, Dong Wu, …, Li-Yan Huang, Ming Zhou, Kai-Hong Zhao
- Biochemistry, 10.1021/acs.biochem.3c00110
Liquid-liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation
- Xinrui Gui, Shuang Feng, Zilong Li, …, Bernd Reif, Bingyang Shi, Zheng Niu
- J Biol Chem, 10.1016/j.jbc.2023.102926
Crosslink-Induced Conformation Change of Intrinsically Disordered Proteins Have a Nontrivial Effect on Phase Separation Dynamics and Thermodynamics
- Linge Li, Zhonghuai Hou, Linge Li, …, Zhonghuai Hou, Linge Li, Zhonghuai Hou
- J Phys Chem B, 10.1021/acs.jpcb.3c01728
Stressing the role of a short linear motif in ataxin-2 condensation
- Tom Scheidt, Hao Ruan, Miao Yu, …, Hao Ruan, Miao Yu, Edward A Lemke
- Mol Cell, 10.1016/j.molcel.2023.05.024
We con-dense if we want to; We can’t leave AZUL outside
- Thuy P Dao, Carlos A Castañeda, Thuy P Dao, …, Carlos A Castañeda, Thuy P Dao, Carlos A Castañeda
- Structure, 10.1016/j.str.2023.03.006
FIREBALL: A tool to fit protein phase diagrams based on mean-field theories for polymer solutions
- Mina Farag, Alex S Holehouse, Xiangze Zeng, …, Alex S Holehouse, Xiangze Zeng, Rohit V Pappu
- bioRxiv : the preprint server for biology, 10.1101/2023.03.19.533322
Towards sequence-based principles for protein phase separation predictions
- Michele Vendruscolo, Monika Fuxreiter, Michele Vendruscolo, Monika Fuxreiter, Michele Vendruscolo, Monika Fuxreiter
- Curr Opin Chem Biol, 10.1016/j.cbpa.2023.102317
Toward a high-resolution mechanism of intrinsically disordered protein self-assembly
- Naotaka Sekiyama, Ryoga Kobayashi, Takashi S Kodama
- J Biochem, 10.1093/jb/mvad056
Sequence Tendency for the Interaction between Low-Complexity Intrinsically Disordered Proteins
- Moxin Zhang, Bin Xue, Qingtai Li, …, Yi Cao, Wei Wang, Jingyuan Li
- None, 10.1021/jacsau.2c00414
Phase Separation in Mixtures of Prion-Like Low Complexity Domains is Driven by the Interplay of Homotypic and Heterotypic Interactions
- Mina Farag, Wade M Borcherds, Anne Bremer, Tanja Mittag, Rohit V Pappu
- bioRxiv : the preprint server for biology, 10.1101/2023.03.15.532828
2022 Articles
28 articles
Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation
- Si Wu, Jitao Wen, Sarah Perrett, …, Si Wu, Jitao Wen, Sarah Perrett
- Essays Biochem, 10.1042/ebc20220148
Sequence-Based Prediction of Protein Phase Separation: The Role of Beta-Pairing Propensity
- Pratik Mullick, Antonio Trovato, Pratik Mullick, …, Antonio Trovato, Pratik Mullick, Antonio Trovato
- Biomolecules, 10.3390/biom12121771
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform
- William E Arter, Runzhang Qi, Nadia A Erkamp, …, Peter St George-Hyslop, Simon Alberti, Tuomas P J Knowles
- Nat Commun, 10.1038/s41467-022-35265-7
Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations
- Mina Farag, Samuel R Cohen, Wade M Borcherds, …, Anne Bremer, Tanja Mittag, Rohit V Pappu
- Nat Commun, 10.1038/s41467-022-35370-7
Heterotypic phase separation of Hfq is linked to its roles as an RNA chaperone
- Omer Goldberger, Tamar Szoke, Anat Nussbaum-Shochat, …, Tamar Szoke, Anat Nussbaum-Shochat, Orna Amster-Choder
- Cell Rep, 10.1016/j.celrep.2022.111881
Sequence determinants and solution conditions underlying liquid to solid phase transition
- Yuxuan Li, Kaiqiang You, Tao Peng, …, Kaiqing You, Tao Peng, Tingting Li
- Am J Physiol Cell Physiol, 10.1152/ajpcell.00280.2022
Intrinsically disordered regions that drive phase separation form a robustly distinct protein class
- Ayyam Y Ibrahim, Nathan P Khaodeuanepheng, Dhanush L Amarasekara, …, Nicholas C Fitzkee, Loren E Hough, Steven T Whitten
- J Biol Chem, 10.1016/j.jbc.2022.102801
Structural and functional organization of germ plasm condensates
- Austin Chiappetta, Jeffrey Liao, Siran Tian, …, Jeffrey Liao, Siran Tian, Tatjana Trcek
- Biochem J, 10.1042/bcj20210815
Kinase regulation by liquid-liquid phase separation
- Tania P López-Palacios, Joshua L Andersen, Tania P López-Palacios, …, Joshua L Andersen, Tania P López-Palacios, Joshua L Andersen
- Trends Cell Biol, 10.1016/j.tcb.2022.11.009
dSCOPE: a software to detect sequences critical for liquid-liquid phase separation
- Kai Yu, Zekun Liu, Haoyang Cheng, …, Qi Zhao, Shiyang Kang, Ze-Xian Liu
- Brief Bioinform, 10.1093/bib/bbac550