Phage therapy, viral phage therapy, or phagotherapy is the therapeutic use of bacteriophages for the treatment of pathogenic bacterial infections. This therapeutic approach emerged at the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the Second World War. Bacteriophages, known as phages, are a form of virus that attach to bacterial cells and inject their genome into the cell. The bacteria's production of the viral genome interferes with its ability to function, halting the bacterial infection. The bacterial cell causing the infection is unable to reproduce and instead produces additional phages. Phages are very selective in the strains of bacteria they are effective against. Wikipedia (CC BY-SA 3.0)
2023 Articles
421 articles
Design, Screening, and Characterization of Engineered Phage Endolysins with Extracellular Antibacterial Activity against Gram-Negative Bacteria
- Bingrui Sui, Xinrui Wang, Tianyi Zhao, …, Wenhua Liu, Xiaoxuan Zhang, Can Zhang
- Appl Environ Microbiol, 10.1128/aem.00581-23
Indigenous Oral and Gut Phages Defeat the Deadly NDM-1 Superbug
- Pradeep Kumar Yadalam, Raghavendra Vamsi Anegundi, Ramya Ramadoss, …, M Saravanan, AshokKumar Veeramuthu, Artak Heboyan
- None, 10.1177/11779322231182767
Resistance-resistant antibacterial treatment strategies
- Jonathan I Batchelder, Patricia J Hare, Wendy W K Mok, …, Jonathan I Batchelder, Patricia J Hare, Wendy W K Mok
- None, 10.3389/frabi.2023.1093156
CAUSES OF SUPERINFECTIONS: DEADLY BACTERIA OF TUBERCULOSIS
- Yuriy F Koshak, Volodymyr V Benedykt, Andrii M Prodan, …, Andrii M Prodan, Volodymyr G Dzhyvak, Iryna M Nikitina
- Wiad Lek, 10.36740/wlek202211216
Assessing Acinetobacter baumannii virulence and treatment with a bacteriophage using zebrafish embryos
- Sofia Neto, Ana Vieira, Hugo Oliveira, …, Ana Vieira, Hugo Oliveira, Begoña Espiña
- FASEB J, 10.1096/fj.202300385r
Bactericidal synergism between phage endolysin Ply2660 and cathelicidin LL-37 against vancomycin-resistant Enterococcus faecalis biofilms
- Huihui Zhang, Xinyuan Zhang, Siyu Liang, …, Siguo Liu, Stefan Schwarz, Fang Xie
- NPJ Biofilms Microbiomes, 10.1038/s41522-023-00385-5
Novel antimicrobial strategies to treat multi-drug resistant Staphylococcus aureus infections
- Edward J A Douglas, Sri W Wulandari, Scott D Lovell, …, Sri W Wulandari, Scott D Lovell, Maisem Laabei
- Microb Biotechnol, 10.1111/1751-7915.14268
The Potential of Bacteriophage-Antibiotic Combination Therapy in Treating Infections with Multidrug-Resistant Bacteria
- Abdul-Halim Osman, Fleischer C N Kotey, Alex Odoom, …, Raphael K Yeboah, Nicholas T K D Dayie, Eric S Donkor
- None, 10.3390/antibiotics12081329
Bacteriophages potentiate the effect of antibiotics by eradication of persister cells and killing of biofilm-forming cells
- Javiera Vera-Mansilla, Cecilia A Silva-Valenzuela, Patricio Sánchez, Roberto C Molina-Quiroz
- Res Microbiol, 10.1016/j.resmic.2023.104083
Advancements in bacteriophage therapies and delivery for bacterial infection
- Hannah A Durr, Hannah A Durr, Hannah A Durr, Nic D Leipzig
- None, 10.1039/d2ma00980c
2022 Articles
48 articles
The role of the animal host in the management of bacteriophage resistance during phage therapy
- Baptiste Gaborieau, Laurent Debarbieux, Baptiste Gaborieau, …, Laurent Debarbieux, Baptiste Gaborieau, Laurent Debarbieux
- Curr Opin Virol, 10.1016/j.coviro.2022.101290
Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era
- Hao Ling, Xinyu Lou, Qiuhua Luo, …, Zhonggui He, Mengchi Sun, Jin Sun
- None, 10.1016/j.apsb.2022.05.007
Coping with the ESKAPE pathogens: Evolving strategies, challenges and future prospects
- Chinyere Aloke, Ikechukwu Achilonu, Chinyere Aloke, …, Ikechukwu Achilonu, Chinyere Aloke, Ikechukwu Achilonu
- Microb Pathog, 10.1016/j.micpath.2022.105963
Alternatives Therapeutic Approaches to Conventional Antibiotics: Advantages, Limitations and Potential Application in Medicine
- Hiba Alaoui Mdarhri, Rachid Benmessaoud, Houda Yacoubi, …, Idrissa Diawara, Moulay Mustapha Ennaji, Mohamed Kettani-Halabi
- None, 10.3390/antibiotics11121826
Anti-Biofilm Effect of Bacteriophages and Antibiotics against Uropathogenic Escherichia coli
- Laima Mukane, Karlis Racenis, Dace Rezevska, …, Dace Rezevska, Aivars Petersons, Juta Kroica
- None, 10.3390/antibiotics11121706
CRISPR-Cas System: A Tool to Eliminate Drug-Resistant Gram-Negative Bacteria
- Rajeshwari Kundar, Karuna Gokarn, Rajeshwari Kundar, …, Karuna Gokarn, Rajeshwari Kundar, Karuna Gokarn
- None, 10.3390/ph15121498
The synergistic effect of using bacteriophages and chitosan nanoparticles against pathogenic bacteria as a novel therapeutic approach
- Abdallah S Abdelsattar, Aghapy Yermans Yakoup, Yousef Khaled, …, Yousef Khaled, Anan Safwat, Ayman El-Shibiny
- Int J Biol Macromol, 10.1016/j.ijbiomac.2022.12.246
Chimeric Peptidoglycan Hydrolases Kill Staphylococcal Mastitis Isolates in Raw Milk and within Bovine Mammary Gland Epithelial Cells
- Anja P Keller, Shera Ly, Steven Daetwyler, …, Fritz Eichenseher, Martin J Loessner, Mathias Schmelcher
- Viruses, 10.3390/v14122801
Comparing In Vitro Faecal Fermentation Methods as Surrogates for Phage Therapy Application
- Norbert Ács, Ross Holohan, Laura J Dunne, …, Lorraine A Draper, R Paul Ross, Colin Hill
- Viruses, 10.3390/v14122632