Channel: Phage therapy

Phage therapy, viral phage therapy, or phagotherapy is the therapeutic use of bacteriophages for the treatment of pathogenic bacterial infections. This therapeutic approach emerged at the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the Second World War. Bacteriophages, known as phages, are a form of virus that attach to bacterial cells and inject their genome into the cell. The bacteria's production of the viral genome interferes with its ability to function, halting the bacterial infection. The bacterial cell causing the infection is unable to reproduce and instead produces additional phages. Phages are very selective in the strains of bacteria they are effective against. Wikipedia (CC BY-SA 3.0)

    2023 Articles

    421 articles

    Design, Screening, and Characterization of Engineered Phage Endolysins with Extracellular Antibacterial Activity against Gram-Negative Bacteria

    • Bingrui Sui, Xinrui Wang, Tianyi Zhao, …, Wenhua Liu, Xiaoxuan Zhang, Can Zhang
    • Appl Environ Microbiol, 10.1128/aem.00581-23
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    Indigenous Oral and Gut Phages Defeat the Deadly NDM-1 Superbug

    • Pradeep Kumar Yadalam, Raghavendra Vamsi Anegundi, Ramya Ramadoss, …, M Saravanan, AshokKumar Veeramuthu, Artak Heboyan
    • None, 10.1177/11779322231182767
    Comment Section

    Resistance-resistant antibacterial treatment strategies

    • Jonathan I Batchelder, Patricia J Hare, Wendy W K Mok, …, Jonathan I Batchelder, Patricia J Hare, Wendy W K Mok
    • None, 10.3389/frabi.2023.1093156
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    CAUSES OF SUPERINFECTIONS: DEADLY BACTERIA OF TUBERCULOSIS

    • Yuriy F Koshak, Volodymyr V Benedykt, Andrii M Prodan, …, Andrii M Prodan, Volodymyr G Dzhyvak, Iryna M Nikitina
    • Wiad Lek, 10.36740/wlek202211216
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    Assessing Acinetobacter baumannii virulence and treatment with a bacteriophage using zebrafish embryos

    • Sofia Neto, Ana Vieira, Hugo Oliveira, …, Ana Vieira, Hugo Oliveira, Begoña Espiña
    • FASEB J, 10.1096/fj.202300385r
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    Bactericidal synergism between phage endolysin Ply2660 and cathelicidin LL-37 against vancomycin-resistant Enterococcus faecalis biofilms

    • Huihui Zhang, Xinyuan Zhang, Siyu Liang, …, Siguo Liu, Stefan Schwarz, Fang Xie
    • NPJ Biofilms Microbiomes, 10.1038/s41522-023-00385-5
    Comment Section

    Novel antimicrobial strategies to treat multi-drug resistant Staphylococcus aureus infections

    • Edward J A Douglas, Sri W Wulandari, Scott D Lovell, …, Sri W Wulandari, Scott D Lovell, Maisem Laabei
    • Microb Biotechnol, 10.1111/1751-7915.14268
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    The Potential of Bacteriophage-Antibiotic Combination Therapy in Treating Infections with Multidrug-Resistant Bacteria

    • Abdul-Halim Osman, Fleischer C N Kotey, Alex Odoom, …, Raphael K Yeboah, Nicholas T K D Dayie, Eric S Donkor
    • None, 10.3390/antibiotics12081329
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    Bacteriophages potentiate the effect of antibiotics by eradication of persister cells and killing of biofilm-forming cells

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    Advancements in bacteriophage therapies and delivery for bacterial infection

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    2022 Articles

    48 articles

    The role of the animal host in the management of bacteriophage resistance during phage therapy

    • Baptiste Gaborieau, Laurent Debarbieux, Baptiste Gaborieau, …, Laurent Debarbieux, Baptiste Gaborieau, Laurent Debarbieux
    • Curr Opin Virol, 10.1016/j.coviro.2022.101290
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    Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era

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    Coping with the ESKAPE pathogens: Evolving strategies, challenges and future prospects

    • Chinyere Aloke, Ikechukwu Achilonu, Chinyere Aloke, …, Ikechukwu Achilonu, Chinyere Aloke, Ikechukwu Achilonu
    • Microb Pathog, 10.1016/j.micpath.2022.105963
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    Alternatives Therapeutic Approaches to Conventional Antibiotics: Advantages, Limitations and Potential Application in Medicine

    • Hiba Alaoui Mdarhri, Rachid Benmessaoud, Houda Yacoubi, …, Idrissa Diawara, Moulay Mustapha Ennaji, Mohamed Kettani-Halabi
    • None, 10.3390/antibiotics11121826
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    Anti-Biofilm Effect of Bacteriophages and Antibiotics against Uropathogenic Escherichia coli

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    CRISPR-Cas System: A Tool to Eliminate Drug-Resistant Gram-Negative Bacteria

    • Rajeshwari Kundar, Karuna Gokarn, Rajeshwari Kundar, …, Karuna Gokarn, Rajeshwari Kundar, Karuna Gokarn
    • None, 10.3390/ph15121498
    Comment Section

    The synergistic effect of using bacteriophages and chitosan nanoparticles against pathogenic bacteria as a novel therapeutic approach

    • Abdallah S Abdelsattar, Aghapy Yermans Yakoup, Yousef Khaled, …, Yousef Khaled, Anan Safwat, Ayman El-Shibiny
    • Int J Biol Macromol, 10.1016/j.ijbiomac.2022.12.246
    Comment Section

    Chimeric Peptidoglycan Hydrolases Kill Staphylococcal Mastitis Isolates in Raw Milk and within Bovine Mammary Gland Epithelial Cells

    • Anja P Keller, Shera Ly, Steven Daetwyler, …, Fritz Eichenseher, Martin J Loessner, Mathias Schmelcher
    • Viruses, 10.3390/v14122801
    Comment Section

    Comparing In Vitro Faecal Fermentation Methods as Surrogates for Phage Therapy Application

    • Norbert Ács, Ross Holohan, Laura J Dunne, …, Lorraine A Draper, R Paul Ross, Colin Hill
    • Viruses, 10.3390/v14122632
    Comment Section