Parkinson's disease (PD), or simply Parkinson's, is a chronic degenerative disorder of the central nervous system that affects both the motor system and non-motor systems. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. Early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Problems may also arise with cognition, behaviour, sleep, and sensory systems. Parkinson's disease dementia becomes common in advanced stages of the disease. Wikipedia (CC BY-SA 3.0)
2023 Articles
7 930 articles
Gut microbes modulate neurodegeneration
- Tanya Jain, Yue-Ming Li, Tanya Jain, …, Yue-Ming Li, Tanya Jain, Yue-Ming Li
- Science, 10.1126/science.adf9548
How iron can drive neurodegeneration
- Boyd Kenkhuis, Ashley I Bush, Scott Ayton, …, Boyd Kenkhuis, Ashley I Bush, Scott Ayton
- Trends Neurosci, 10.1016/j.tins.2023.02.003
Alzheimer’s disease pathology concomitant with memory impairment in late-onset multiple system atrophy
- Yasuo Miki, ConceiĆ§Ć£o Bettencourt, Zane Jaunmuktane, …, Janice L Holton, Thomas T Warner, Koichi Wakabayashi
- Neuropathol Appl Neurobiol, 10.1111/nan.12878
Early GCase activity is a predictor of long-term cognitive decline in Parkinson’s disease
- Linn Oftedal, Johannes Lange, Kenn Freddy Pedersen, …, Ole-BjĆørn Tysnes, Guido Alves, Jodi Maple-GrĆødem
- Transl Neurodegener, 10.1186/s40035-023-00373-x
Cross-Ī² helical filaments of Tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia
- Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, …, Ruben Vidal, Bernardino Ghetti, Wen Jiang
- Acta Neuropathol, 10.1007/s00401-023-02563-3
Introduction to The Special Issue: Novel Molecular Pathways and Therapeutic Challenges in Neurodegenerative Diseases
- Jagannatha Rao Kosagisharaf, Muralidhar L Hegde, Jagannatha Rao Kosagisharaf, …, Muralidhar L Hegde, Jagannatha Rao Kosagisharaf, Muralidhar L Hegde
- J Alzheimers Dis, 10.3233/jad-230622
Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer’s disease but not Lewy body dementias
- Yuek Ling Chai, Jasinda H Lee, Joyce R Chong, …, Christopher P Chen, Dag Aarsland, Mitchell K P Lai
- J Neuroinflammation, 10.1186/s12974-023-02789-8
Altered localization of nucleoporin 98 in primary tauopathies
- John R Dickson, Matthew P Frosch, Bradley T Hyman, …, John R Dickson, Matthew P Frosch, Bradley T Hyman
- Brain, 10.1093/braincomms/fcac334
Comparison of Clinical, Genetic, and Pathologic Features of Limbic and Diffuse Transactive Response DNA-Binding Protein 43 Pathology in Alzheimer’s Disease Neuropathologic Spectrum
- Arenn F Carlos, Mary M Machulda, Matthew H Rutledge, …, Dennis W Dickson, Ronald C Petersen, Keith A Josephs
- J Alzheimers Dis, 10.3233/jad-221094
Cognitive and Neuropsychological Profiles in Alzheimer’s Disease and Primary Age-Related Tauopathy and the Influence of Comorbid Neuropathologies
- Jamie M Walker, Mitzi M Gonzales, William Goette, …, Charles L White Iii, John F Crary, Timothy E Richardson
- J Alzheimers Dis, 10.3233/jad-230022
2022 Articles
850 articles
Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study
- Anna Raunio, Ville Kivistƶ, Mia Kero, …, Pentti J Tienari, Henri Puttonen, Liisa Myllykangas
- Acta Neuropathol Commun, 10.1186/s40478-022-01487-5
LATE-NC staging in routine neuropathologic diagnosis: an update
- Peter T Nelson, Edward B Lee, Matthew D Cykowski, …, Julie A Schneider, Dennis W Dickson, Manuela Neumann
- Acta Neuropathol, 10.1007/s00401-022-02524-2
Granulovacuolar degeneration bodies are independently induced by tau and Ī±-synuclein pathology
- Marta Jorge-Oliva, Jasper F M Smits, Vera I Wiersma, …, Vera I Wiersma, Jeroen J M Hoozemans, Wiep Scheper
- Alzheimers Res Ther, 10.1186/s13195-022-01128-y
TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
- Yuichi Riku, Mari Yoshida, Yasushi Iwasaki, …, Gen Sobue, Masahisa Katsuno, Shinsuke Ishigaki
- Int J Mol Sci, 10.3390/ijms232415755
Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging
- Jolien Perneel, Manuela Neumann, Bavo Heeman, …, JĆŗlia Faura, Rosa Rademakers, Ian R A Mackenzie
- Acta Neuropathol, 10.1007/s00401-022-02531-3
The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals
- Jamie M Walker, Shiva Kazempour Dehkordi, Jeff Schaffert, …, Charles L White Iii, Timothy E Richardson, Habil Zare
- J Alzheimers Dis, 10.3233/jad-220898
The associations of cerebrospinal fluid biomarkers with cognition, and rapid eye movement sleep behavior disorder in early Parkinson’s disease
- Mingzhu Tao, Kaixin Dou, Yijie Xie, …, Yijie Xie, Binghui Hou, Anmu Xie
- None, 10.3389/fnins.2022.1049118
Association Between Orthostatic Hypotension and Dementia in Patients With Parkinson Disease and Multiple System Atrophy
- IƱigo Ruiz Barrio, Yasuo Miki, Zane T Jaunmuktane, …, Zane T Jaunmuktane, Thomas Warner, Eduardo De Pablo-Fernandez
- Neurology, 10.1212/wnl.0000000000201659
Ingenuity pathway analysis of Ī±-synuclein predicts potential signaling pathways, network molecules, biological functions, and its role in neurological diseases
- Sharad Kumar Suthar, Sang-Yoon Lee, Sharad Kumar Suthar, Sang-Yoon Lee
- None, 10.3389/fnmol.2022.1029682
Effect of Amyloid on Cognitive Performance in Parkinson’s Disease and Dementia with Lewy Bodies
- Kyoungwon Baik, Hye Ryun Kim, Mincheol Park, …, Young H Sohn, Joon-Kyung Seong, Phil Hyu Lee
- Mov Disord, 10.1002/mds.29295