Inspired by: Milica Radisic
An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context. By acting as a more sophisticated in vitro approximation of complex tissues than standard cell culture, they provide the potential as an alternative to animal models for drug development and toxin testing. Wikipedia (CC BY-SA 3.0)
2023 Articles
2 385 articles
Perfusable cell-laden micropatterned hydrogels for delivery of spatiotemporal vascular-like cues to tissues
- Walter B Varhue, Aditya Rane, Ramon Castellanos-Sanchez, …, Shayn M Peirce, George Christ, Nathan S Swami
- None, 10.1016/j.ooc.2022.100017
High-Resolution Novel Indirect Bioprinting of Low-Viscosity Cell-Laden Hydrogels via Model-Support Bioink Interaction
- Edgar Y S Tan, Ratima Suntornnond, Wai Yee Yeong, Edgar Y S Tan, Ratima Suntornnond, Wai Yee Yeong
- None, 10.1089/3dp.2020.0153
Co-culture system of human skin equivalents with mouse neural spheroids
- Satoshi Inagaki, Yuya Morimoto, Ikuo K Suzuki, …, Ikuo K Suzuki, Kazuo Emoto, Shoji Takeuchi
- J Biosci Bioeng, 10.1016/j.jbiosc.2023.05.008
Microfluidic Systems for Neural Cell Studies
- Eleftheria Babaliari, Anthi Ranella, Emmanuel Stratakis, Eleftheria Babaliari, Anthi Ranella, Emmanuel Stratakis
- None, 10.3390/bioengineering10080902
Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles
- Suji Choi, Keel Yong Lee, Sean L Kim, …, William T Pu, Andreas R Bausch, Kevin Kit Parker
- Nat Mater, 10.1038/s41563-023-01611-3
The Influence of Fluid Shear Stress on Bone and Cancer Cells Proliferation and Distribution
- Lahcen Akerkouch, Haneesh Jasuja, Kalpana Katti, …, Kalpana Katti, Dinesh Katti, Trung Le
- Ann Biomed Eng, 10.1007/s10439-022-03123-8
Cardiovascular human organ-on-a-chip platform for disease modeling, drug development, and personalized therapy
- Astha Khanna, Beu P Oropeza, Ngan F Huang
- J Biomed Mater Res A, 10.1002/jbm.a.37602
Microengineering double layer hydrogel structures towards the recapitulation of the hematopoietic stem cell niche
- Pilar Carreras, Rodrigo Cortrim Chaves, Miguel Gallardo, Alejandra Ortiz, Joaquin Martinez Lopez, Samuel K Sia
- Sci Bull (Beijing), 10.1016/j.scib.2018.09.003
Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor
- Kihak Gwon, Daheui Choi, JosĂ© M de Hoyos-Vega, …, Takeshi Saito, Gulnaz Stybayeva, Alexander Revzin
- None, 10.1016/j.bioactmat.2023.05.009
Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods
- Qing Liu, Zhen Liu, Hongyu Gu, …, Yuguo Lei, Zhanqi Wang, Haishuang Lin
- None, 10.1016/j.reth.2022.12.001
2022 Articles
251 articles
Interstitial flow promotes the formation of functional microvascular networks in vitro through upregulation of matrix metalloproteinase-2
- Shun Zhang, Zhengpeng Wan, Georgios Pavlou, …, Amy X Zhong, Liling Xu, Roger D Kamm
- Adv Mater, 10.1002/adfm.202206767
A low-cost and open-source measurement system to determine the Young’s and shear moduli and Poisson’s ratio of soft materials using a Raspberry Pi camera module and 3D printed parts
- Matthew Sands, Jinki Kim, Matthew Sands, Jinki Kim
- None, 10.1016/j.ohx.2022.e00386
Latest developments in engineered skeletal muscle tissues for drug discovery and development
- Serge Ostrovidov, Murugan Ramalingam, Hojae Bae, …, Toshinori Fujie, Xuetao Shi, Hirokazu Kaji
- Expert Opin Drug Discov, 10.1080/17460441.2023.2160438
Gravity-driven microfluidic device placed on a slow-tilting table enables constant unidirectional perfusion culture of human induced pluripotent stem cells
- Nuttakrit Limjanthong, Yoshikatsu Tohbaru, Taiga Okamoto, …, Toshiyuki Kanamori, Shinji Sugiura, Kiyoshi Ohnuma
- J Biosci Bioeng, 10.1016/j.jbiosc.2022.11.007
In Vitro Differentiation of Myoblast Cell Lines on Spider Silk Scaffolds in a Rotating Bioreactor for Vascular Tissue Engineering
- Doha Obed, Nadjib Dastagir, Christina Liebsch, …, Sarah Strauss, Peter M Vogt, Khaled Dastagir
- None, 10.3390/jpm12121986
Laser-Structured Si and PLGA Inhibit the Neuro2a Differentiation in Mono- and Co-Culture with Glia
- Despoina Angelaki, Paraskevi Kavatzikidou, Costas Fotakis, …, Costas Fotakis, Emmanuel Stratakis, Anthi Ranella
- Tissue Eng Regen Med, 10.1007/s13770-022-00497-7
Current Advances in 3D Dynamic Cell Culture Systems
- Xin Huang, Zhengxiang Huang, Weidong Gao, …, Yinghong Zhou, Lan Xiao, Yin Xiao
- None, 10.3390/gels8120829
Bioengineering of High Cell Density Tissues with Hierarchical Vascular Networks for Ex Vivo Whole Organs
- Peizheng Wu, Hiroki Asada, Masataka Hakamada, …, Hiroki Asada, Masataka Hakamada, Mamoru Mabuchi
- Adv Mater, 10.1002/adma.202209149
Biosensor integrated tissue chips and their applications on Earth and in space
- Anne Yau, Zizheng Wang, Nadya Ponthempilly, …, Yi Zhang, Xueju Wang, Yupeng Chen
- Biosens Bioelectron, 10.1016/j.bios.2022.114820
Efficient hepatic differentiation of hydrogel microsphere-encapsulated human pluripotent stem cells for engineering prevascularized liver tissue
- Shuai Deng, Xiaoyu Zhao, Yanlun Zhu, …, Mingqiang Li, Yu Tao, Hon Fai Chan
- Biofabrication, 10.1088/1758-5090/aca79b