Inspired by: Charles Brenner
Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism, and has been shown to play a role in reducing ageing. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other, nicotinamide. NAD exists in two forms: an oxidized and reduced form, abbreviated as NAD+ and NADH (H for hydrogen), respectively. Wikipedia (CC BY-SA 3.0)
2023 Articles
2 075 articles
Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid
- Shengyu Feng, Liuling Guo, Hao Wang, …, Hao Wang, Shanshan Yang, Hailiang Liu
- Commun Biol, 10.1038/s42003-023-04613-8
Mitochondria in Ageing and Diseases: Partie Deux
- Hannah Tobias-Wallingford, Giuseppe Coppotelli, Jaime M Ross, …, Hannah Tobias-Wallingford, Giuseppe Coppotelli, Jaime M Ross
- Int J Mol Sci, 10.3390/ijms241210359
Quantification of localized NAD + changes reveals unique specificity of NAD + regulation in the hypothalamus
- Sean Johnson, Kiyoshi Yoshioka, Cynthia S Brace, …, Kiyoshi Yoshioka, Cynthia S Brace, Shin-Ichiro Imai
- None, 10.1038/s41514-023-00098-1
Both prolonged high-fat diet consumption and calorie restriction boost hepatic NAD+ metabolism in mice
- Xiaojing Wei, Chuanfei Wei, Yutian Tan, …, Zhao Yang, Jianqun Yan, Xiao Luo
- J Nutr Biochem, 10.1016/j.jnutbio.2023.109296
Involvement of eNAMPT/TLR4 inflammatory signaling in progression of non-alcoholic fatty liver disease, steatohepatitis, and fibrosis
- Belinda L Sun, Xiaoguang Sun, Carrie L Kempf, …, Cristina Travelli, Donna D Zhang, Joe G N Garcia
- FASEB J, 10.1096/fj.202201972rr
Evolution, mechanism and limits of dietary restriction induced health benefits & longevity
- Friedrich Becker, Marthe M Behrends, K Lenhard Rudolph, …, Friedrich Becker, Marthe M Behrends, K Lenhard Rudolph
- Redox Biol, 10.1016/j.redox.2023.102725
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study
- Karol Mateusz Pencina, Rodrigo Valderrabano, Benjamin Wipper, …, David A Sinclair, David Livingston, Shalender Bhasin
- J Clin Endocrinol Metab, 10.1210/clinem/dgad027
The I148M PNPLA3 variant mitigates niacin beneficial effects: How the genetic screening in non-alcoholic fatty liver disease patients gains value
- Erika Paolini, Miriam Longo, Marica Meroni, …, Marco Maggioni, Anna Ludovica Fracanzani, Paola Dongiovanni
- None, 10.3389/fnut.2023.1101341
NAD metabolism: Role in senescence regulation and aging
- Claudia Christiano Silva Chini, Heidi Soares Cordeiro, Ngan Le Kim Tran, Eduardo Nunes Chini
- Aging Cell, 10.1111/acel.13920
A mechanistic view of the use of cold temperature in the treatment of cancer
- Tatiana P Grazioso, Nabil Djouder, Tatiana P Grazioso, …, Nabil Djouder, Tatiana P Grazioso, Nabil Djouder
- None, 10.1016/j.isci.2023.106511
2022 Articles
219 articles
Emerging role of aging in the progression of NAFLD to HCC
- Yongyuan He, Yinghong Su, Chengcheng Duan, …, Yingting Zhang, Xiaofei An, Ming He
- Ageing Res Rev, 10.1016/j.arr.2022.101833
The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes
- Cassandra B Higgins, Joshua A Adams, Matthew H Ward, …, Ilona Wandzik, Laura G Schuettpelz, Brian J DeBosch
- J Biol Chem, 10.1016/j.jbc.2022.102835
The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
- Rika Ohkubo, Wei-Chieh Mu, Chih-Ling Wang, …, Norma Neff, Cole M Haynes, Danica Chen
- Cell Rep, 10.1016/j.celrep.2022.111803
Human centenarian-associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids
- Jan Frohlich, Marco Raffaele, Helena Skalova, …, Pille Pata, Vera Gorbunova, Manlio Vinciguerra
- Geroscience, 10.1007/s11357-022-00713-1
Molecular properties and regulation of NAD+ kinase (NADK)
- Shin-Ichi Oka, Allen Sam Titus, Daniela Zablocki, …, Allen Sam Titus, Daniela Zablocki, Junichi Sadoshima
- Redox Biol, 10.1016/j.redox.2022.102561
Aberrant NAD synthetic flux in podocytes under diabetic conditions and effects of indoleamine 2,3-dioxygenase on promoting de novo NAD synthesis
- Yuhua Zhang, Xingchen Zhao, Cuili Li, …, Meijun Si, Xinling Liang, Yuanhan Chen
- Biochem Biophys Res Commun, 10.1016/j.bbrc.2022.12.059
Angiotensin(1-7) attenuates visceral adipose tissue expansion and lipogenesis by suppression of endoplasmic reticulum stress via Mas receptor
- Chifa Ma, Tingting Shi, Lini Song, …, Lini Song, Jingyi Liu, Mingxia Yuan
- None, 10.1186/s12986-022-00716-x
Methods to Assess the Role of PARPs in Regulating Mitochondrial Oxidative Function
- Tünde Kovács, Boglárka Rauch, Edit Mikó, …, Boglárka Rauch, Edit Mikó, Péter Bai
- Methods Mol Biol, 10.1007/978-1-0716-2891-1_14
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
- Jun Guo, Xiuqing Huang, Lin Dou, …, Tao Shen, Weiqing Tang, Jian Li
- Signal Transduct Target Ther, 10.1038/s41392-022-01251-0
Ketogenic Diet Increases Serum and White Adipose Tissue SIRT1 Expression in Mice
- Rossella Tozzi, Federica Campolo, Enke Baldini, …, Salvatore Ulisse, Lucio Gnessi, Stefania Mariani
- Int J Mol Sci, 10.3390/ijms232415860