Channel: Mitochondrial dysfunction

Dysfunctional mitochondria contribute to aging through interfering with intracellular signaling and triggering inflammatory reactions. Wikipedia (CC BY-SA 3.0)

2023 Articles

60 330 articles

Mitochondria: A “pacemaker” for species-specific development

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Mitochondrial double membrane fission: A mystery solved?

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Resilient brains run out of (c)GAS

  • Andrea Francesca M Salvador, Andrea Francesca M Salvador, Andrea Francesca M Salvador, …, Jonathan Kipnis, Andrea Francesca M Salvador, Jonathan Kipnis
  • Nat Immunol, 10.1038/s41590-023-01485-2
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Mitochondrial stress and aging: Lessons from C. elegans

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Peritoneal signalling improves hippocampal BDNF expression in aged mice

  • Yoshinori Takei, Yoko Amagase, Atsushi Sugiyama, …, Yoshinori Takei, Yoko Amagase, Atsushi Sugiyama
  • Aging (Albany NY), 10.18632/aging.204919
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Epigenetic codes of mitochondrial homeostasis

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Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis

  • Venus Marie Gaela, Liuh-Yow Chen, Venus Marie Gaela, …, Liuh-Yow Chen, Venus Marie Gaela, Liuh-Yow Chen
  • Mol Cell, 10.1016/j.molcel.2023.03.012
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Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants

  • Annika Traa, Hazel Shields, Abdelrahman AlOkda, …, Zenith D Rudich, Bokang Ko, Jeremy M Van Raamsdonk
  • None, 10.3389/fragi.2023.1145198
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Reverse electron transfer is activated during aging and contributes to aging and age-related disease

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2022 Articles

6 787 articles

The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster

  • Kaniz Fatima Binte Hossain, Anjaneyulu Murari, Bibhuti Mishra, …, Anjaneyulu Murari, Bibhuti Mishra, Edward Owusu-Ansah
  • Sci Rep, 10.1038/s41598-022-26414-5
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Single short reprogramming early in life increases healthspan

  • Jean-Marc Lemaitre, Ollivier Milhavet, Ollivier Milhavet, …, Jean-Marc Lemaitre, Ollivier Milhavet, Jean-Marc Lemaitre
  • Aging (Albany NY), 10.18632/aging.204457
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Mitochondrial genome recovery by ATFS-1 is essential for development after starvation

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Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts

  • Sophia Wedel, Ines Martic, Lena Guerrero Navarro, …, Gerhard Pierer, Pidder Jansen-Dürr, Maria Cavinato
  • Aging Cell, 10.1111/acel.13752
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Investigating mitochondrial fission, fusion, and autophagy in retinal pigment epithelium from donors with age-related macular degeneration

  • Cody R Fisher, Adam A Shaaeli, Mara C Ebeling, …, Mara C Ebeling, Sandra R Montezuma, Deborah A Ferrington
  • Sci Rep, 10.1038/s41598-022-26012-5
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Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity

  • Sonja K Soo, Annika Traa, Zenith D Rudich, …, Alibek Moldakozhayev, Meeta Mistry, Jeremy M Van Raamsdonk
  • Aging Cell, 10.1111/acel.13740
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Cilia bent out of shape over dysfunctional astrocyte mitochondria

  • Rachel M Bear, Tamara Caspary, Rachel M Bear, …, Tamara Caspary, Rachel M Bear, Tamara Caspary
  • J Cell Biol, 10.1083/jcb.202211123
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Miro1 R272Q disrupts mitochondrial calcium handling and neurotransmitter uptake in dopaminergic neurons

  • Lisa Schwarz, Karan Sharma, Lorenzo D Dodi, …, Petra Fallier-Becker, Nicolas Casadei, Julia C Fitzgerald
  • None, 10.3389/fnmol.2022.966209
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How a fibroblast ages: a role for bone morphogenetic protein 4 in protecting lung fibroblasts from senescence in pulmonary fibrosis

  • Jeffrey C Horowitz, Ana L Mora, Jeffrey C Horowitz, …, Laszlo Farkas, Jeffrey C Horowitz, Ana L Mora
  • Eur Respir J, 10.1183/13993003.01702-2022
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Age-associated alterations of brain mitochondria energetics

  • Timur Gainutdinov, Zemfira Gizatullina, Grazyna Debska-Vielhaber, …, Robert E Feldmann, Zulfiya Orynbayeva, Frank Norbert Gellerich
  • Biochem Biophys Res Commun, 10.1016/j.bbrc.2022.12.070
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