Inspired by: Nir Barzilai
Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes. There is some evidence metformin may be helpful in extending lifespan, even in otherwise healthy people. It has received substantial interest as an agent that delays aging, possibly through similar mechanisms as its treatment of diabetes (insulin and carbohydrate regulation). Wikipedia (CC BY-SA 3.0)
2023 Articles
20 893 articles
Design and Synthesis of AMPK Activators and GDF15 Inducers
- Meijian Zhang, Andrea Bagán, Donna Martínez, …, Santiago Vázquez, Carmen Escolano, Manuel Vázquez-Carrera
- Molecules, 10.3390/molecules28145468
Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail
- Jonathan J Petrocelli, Naomi M M P de Hart, Marisa J Lang, …, Amandine Chaix, Katsuhiko Funai, Micah J Drummond
- Aging (Albany NY), 10.18632/aging.204600
Gut microbes modulate neurodegeneration
- Tanya Jain, Yue-Ming Li, Tanya Jain, …, Yue-Ming Li, Tanya Jain, Yue-Ming Li
- Science, 10.1126/science.adf9548
Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment
- Jonathan J Petrocelli, Alec I McKenzie, Naomi M M P de Hart, …, Katsuhiko Funai, Christopher S Fry, Micah J Drummond
- Aging Cell, 10.1111/acel.13936
Effects of Urocortin 2 Gene Transfer on Glucose Disposal in Insulin-Resistant db/db Mice on Metformin
- Mei Hua Gao, Dimosthenis Giamouridis, N Chin Lai, …, N Chin Lai, Tracy Guo, H Kirk Hammond
- Hum Gene Ther, 10.1089/hum.2023.052
Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes
- Kaori Hozumi, Kenji Sugawara, Takaya Ishihara, …, Takaya Ishihara, Naotada Ishihara, Wataru Ogawa
- Sci Rep, 10.1038/s41598-023-27689-y
Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
- Shan Luo, Ian Chi Kei Wong, Celine Sze Ling Chui, …, Yuan Huang, Catherine Mary Schooling, Shiu Lun Au Yeung
- Lancet Healthy Longev, 10.1016/s2666-7568(23)00085-5
Metformin extends the chronological lifespan of fission yeast by altering energy metabolism and stress resistance capacity
- Ceren Şeylan, Çağatay Tarhan, Ceren Şeylan, …, Çağatay Tarhan, Ceren Şeylan, Çağatay Tarhan
- FEMS Yeast Res, 10.1093/femsyr/foad018
Effect of Sirolimus/Metformin Co-Treatment on Hyperglycemia and Cellular Respiration in BALB/c Mice
- Alia Albawardi, Dhanya Saraswathiamma, Charu Sharma, …, Abdulghani Elomami, Abdul-Kader Souid, Saeeda Almarzooqi
- Int J Mol Sci, 10.3390/ijms24021223
New cardiac targets for empagliflozin: O-GlcNAcylation, CaMKII, and calcium handling
- Bence Hegyi, Donald M Bers, Bence Hegyi, …, Donald M Bers, Bence Hegyi, Donald M Bers
- Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00003.2023
2022 Articles
2 498 articles
Diabetes Retinopathy: New Ways to Detect and Treat
- Todd A Lydic, Julia V Busik, Todd A Lydic, …, Julia V Busik, Todd A Lydic, Julia V Busik
- Methods Mol Biol, 10.1007/978-1-0716-2807-2_6
β-Cell Stress Pathways in Diabetes: Potential Targets for Therapy?
- S M Niazur Rahman, Adria Giacca, S M Niazur Rahman, …, Adria Giacca, S M Niazur Rahman, Adria Giacca
- Endocrinology, 10.1210/endocr/bqac211
Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts
- Aysegul Durak, Aysegul Durak, Aysegul Durak, Belma Turan
- J Physiol Biochem, 10.1007/s13105-022-00939-9
Metformin Improves Burn Wound Healing by Modulating Microenvironmental Fibroblasts and Macrophages
- Liangliang Shi, Zhengying Jiang, Jiaqi Li, …, Haiyong Ao, Guanghua Guo, Mingzhuo Liu
- Cells, 10.3390/cells11244094
Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway
- Jin-Yun Zhao, Xiao-Long Sheng, Cheng-Jun Li, …, Hong-Bin Lu, Chun-Yue Duan, Jian-Zhong Hu
- None, 10.4103/1673-5374.360245
Ranolazine Attenuates Brain Inflammation in a Rat Model of Type 2 Diabetes
- Velia Cassano, Martina Tallarico, Giuseppe Armentaro, …, Giovambattista De Sarro, Marta Letizia Hribal, Angela Sciacqua
- Int J Mol Sci, 10.3390/ijms232416160
Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models
- Nan Fang Wang, Toni Rose Jue, Jeff Holst, …, Toni Rose Jue, Jeff Holst, Jennifer H Gunter
- BJU Int, 10.1002/bco2.187
Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake
- Kai Liu, Bo Liu, Gary A Wittert, …, Campbell H Thompson, Amy T Hutchison, Leonie K Heilbronn
- Obes Res Clin Pract, 10.1016/j.orcp.2022.12.001
Sex Matters in Aging. The Canagliflozin Story
- Jackson Wezeman, Warren Ladiges, Jackson Wezeman, Warren Ladiges
- None, 10.31491/apt.2022.09.091
Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1
- Rola Hammoud, Rola Hammoud, Rola Hammoud, Daniel J Drucker, Rola Hammoud, Daniel J Drucker
- Nat Rev Endocrinol, 10.1038/s41574-022-00783-3