Islet transplantation emerged as a viable option for the treatment of insulin requiring diabetes in the early 1970s with steady progress over the following three decades. Clinical trials as of 2008 have shown that insulin independence and improved metabolic control can be reproducibly obtained after transplantation of cadaveric donor islets into patients with unstable type 1 diabetes. Wikipedia (CC BY-SA 3.0)
2023 Articles
309 articles
Reprogramming of pancreatic islet cells for regeneration and rejuvenation
- Michitada Hirano, Yasuhiro Yamada
- Curr Opin Genet Dev, 10.1016/j.gde.2023.102099
Human stomach tissue as alternative source of insulin-producing cells
- Eelco J P de Koning, Eelco J P de Koning, Eelco J P de Koning, Françoise Carlotti, Eelco J P de Koning, Françoise Carlotti
- Nat Rev Endocrinol, 10.1038/s41574-023-00867-8
Validating expression of beta cell maturation-associated genes in human pancreas development
- Daniel M Tremmel, Anna E Mikat, Sakar Gupta, …, Jenna A Menadue, Jon S Odorico, Sara Dutton Sackett
- None, 10.3389/fcell.2023.1103719
Identifying type 2 diabetes risk genes by β-cell CRISPR screening
- Bridget K Wagner, Bridget K Wagner
- Nat Genet, 10.1038/s41588-022-01269-8
The path and surface marker of SC-β cells
- Yinglei Li, Wei Jiang
- Sci Bull (Beijing), 10.1016/j.scib.2019.06.018
Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system
- Shenghui Liang, Jia Zhao, Robert K Baker, …, Elisa Tran, Lisa Zhan, Timothy J Kieffer
- Cell Rep Methods, 10.1016/j.crmeth.2023.100466
Extrahepatic transplantation of 3D cultured stem cell-derived islet organoids on microporous scaffolds
- Daniel Clough, Maya Behrend, Connor Annulis, …, Feiran Li, Scott Soleimanpour, Lonnie D Shea
- Biomater Sci, 10.1039/d3bm00217a
Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells
- Ali H Shilleh, Scott Beard, Holger A Russ, …, Ali H Shilleh, Scott Beard, Holger A Russ
- Stem Cell Reports, 10.1016/j.stemcr.2023.05.010
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
- Punn Augsornworawat, Nathaniel J Hogrebe, Matthew Ishahak, …, Julia R Miller, Leonardo Velazco-Cruz, Jeffrey R Millman
- Nat Cell Biol, 10.1038/s41556-023-01150-8
Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
- Ali H Shilleh, Holger A Russ, Ali H Shilleh, …, Holger A Russ, Ali H Shilleh, Holger A Russ
- Cells, 10.3390/cells12050698
2022 Articles
35 articles
Direct Reprogramming of Somatic Cells into Induced β-Cells: An Overview
- Gloria Narayan, Ronima K R, Gloria Narayan, …, Gloria Narayan, Ronima K R, Rajkumar P Thummer
- Adv Exp Med Biol, 10.1007/5584_2022_756
Glucose-Dependent Insulin Secretion from β Cell Spheroids Is Enhanced by Embedding into Softer Alginate Hydrogels Functionalised with RGD Peptide
- Md Lutful Amin, Kylie Deng, Hien A Tran, …, Reena Singh, Jelena Rnjak-Kovacina, Peter Thorn
- None, 10.3390/bioengineering9120722
In Vivo Bioluminescence for the Detection of the Fate of Pancreatic Islet Organoids Post-transplantation
- Aixia Sun, Elizabeth Kenyon, Mithil Gudi, …, Wen Li, Aitor Aguirre, Ping Wang
- Methods Mol Biol, 10.1007/978-1-0716-2807-2_14
Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I
- Jorge Santini-González, Roberto Castro-Gutierrez, Matthew W Becker, …, Chad Rancourt, Holger A Russ, Edward A Phelps
- Front Endocrinol (Lausanne), 10.3389/fendo.2022.989815
Single-cell transcriptomic and spatial landscapes of the developing human pancreas
- Oladapo Edward Olaniru, Ulrich Kadolsky, Shichina Kannambath, …, Kathy Fung, Pawan Dhami, Shanta J Persaud
- Cell Metab, 10.1016/j.cmet.2022.11.009
Fas Ligand-Modified Scaffolds Protect Stem Cell Derived β-Cells by Modulating Immune Cell Numbers and Polarization
- Feiran Li, Kelly Crumley, Elizabeth Bealer, …, Esma S Yolcu, Haval Shirwan, Lonnie D Shea
- ACS Appl Mater Interfaces, 10.1021/acsami.2c12939
An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells
- Florian M Hermann, Maya Friis Kjærgaard, Chenglei Tian, …, Tiinamaija Tuomi, Ivana Novak, Henrik Semb
- Cell Stem Cell, 10.1016/j.stem.2022.12.001
Tricultured Cell Sheets Develop into Functional Pancreatic Islet Tissue with a Vascular Network
- Jun Homma, Hidekazu Sekine, Tatsuya Shimizu, …, Jun Homma, Hidekazu Sekine, Tatsuya Shimizu
- Tissue Eng Part A, 10.1089/ten.tea.2022.0167
PDX-1: A Promising Therapeutic Target to Reverse Diabetes
- Yanjiao Zhang, Xinyi Fang, Jiahua Wei, …, Haoran Wu, Kaile Ma, Jiaxing Tian
- Biomolecules, 10.3390/biom12121785
Genetic Engineering of Immune Evasive Stem Cell-Derived Islets
- Sara D Sackett, Samuel J Kaplan, Samantha A Mitchell, …, Shane Grey, Danwei Huangfu, Jon Odorico
- Transpl Int, 10.3389/ti.2022.10817