Abnormal chemical structures in the DNA are formed mainly through oxidative stress and environmental factors. A number of molecular processes work continuously to repair this damage. Unfortunately, the results are not perfect, and thus damage accumulates over time. Several review articles have shown that deficient DNA repair, allowing greater accumulation of DNA damages, causes premature aging; and that increased DNA repair facilitates greater longevity. Wikipedia (CC BY-SA 3.0)
2023 Articles
87 237 articles
NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4
- Ilse Delint-Ramirez, Ram Madabhushi, Ilse Delint-Ramirez, …, Ram Madabhushi, Ilse Delint-Ramirez, Ram Madabhushi
- Mol Cell, 10.1016/j.molcel.2023.03.019
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis
- Venus Marie Gaela, Liuh-Yow Chen, Venus Marie Gaela, …, Liuh-Yow Chen, Venus Marie Gaela, Liuh-Yow Chen
- Mol Cell, 10.1016/j.molcel.2023.03.012
Accelerated transcriptional elongation during aging impairs longevity
- Alexander Tyshkovskiy, Sirui Zhang, Vadim N Gladyshev
- Cell Res, 10.1038/s41422-023-00829-9
Variability in MUC5B Expression Is Dependent on Genotype and Endotype in Idiopathic Pulmonary Fibrosis
- Auyon J Ghosh, Matthew Moll, Brian D Hobbs, …, Edwin K Silverman, Ivana V Yang, Craig P Hersh
- Am J Respir Crit Care Med, 10.1164/rccm.202209-1835le
Putting aging on ICE
- Bryan B Teefy, Bérénice A Benayoun, Bryan B Teefy, …, Bérénice A Benayoun, Bryan B Teefy, Bérénice A Benayoun
- Cell Metab, 10.1016/j.cmet.2023.02.012
miR-126-5p affects the chemosensitivity of colorectal cancer cells by regulating SPRED1, ERK1/2 pathway and apoptosis
- Mingshi Xu, Gang Zhang, Xiaofan Gu, …, Fangqin Zhao, Zhongmin Yang, Xiongwen Zhang
- None, 10.1016/j.gendis.2022.05.024
Frontiers in aging special issue: DNA repair and interventions in aging perspective on “loss of epigenetic information as a cause of mammalian aging”
- Ethan D Schaffer, Isabel Beerman, Rafael de Cabo, …, Isabel Beerman, Rafael de Cabo, Robert M Brosh
- None, 10.3389/fragi.2023.1199596
Special Issue “DNA Replication/Repair, and the DNA Damage Response in Human Disease”
- Dong Zhang, Kristin A Eckert, Marietta Y W T Lee, …, Dong Zhang, Kristin A Eckert, Marietta Y W T Lee
- Genes (Basel), 10.3390/genes14040893
Mammalian aging driven by transcription going awry
- Brenna S McCauley, Weiwei Dang
- Trends Genet, 10.1016/j.tig.2023.06.006
Introduction: Progression of the Science of Ageing
- Vera Gorbunova, Andrei Seluanov, Vera Gorbunova, Andrei Seluanov, Vera Gorbunova, Andrei Seluanov
- Subcell Biochem, 10.1007/978-3-031-21410-3_1
2022 Articles
9 566 articles
Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity
- Sonja K Soo, Annika Traa, Zenith D Rudich, …, Alibek Moldakozhayev, Meeta Mistry, Jeremy M Van Raamsdonk
- Aging Cell, 10.1111/acel.13740
Novel homozygous variant in ARL2BP associated with retinitis pigmentosa, situs inversus, and male infertility in a Chinese patient
- Tian Zhu, Hui Li, Xing Wei, …, Wuyi Li, Zixi Sun, Ruifang Sui
- Clin Genet, 10.1111/cge.14278
rdgB knockdown in neurons reduced nocturnal sleep in Drosophila melanogaster
- Riho Kobayashi, Yuko Yamashita, Hiroko Suzuki, …, Sena Hatori, Jun Tomita, Kazuhiko Kume
- Biochem Biophys Res Commun, 10.1016/j.bbrc.2022.12.043
Response: ‘letter to the editor: emerging gene therapy products for RPGR-associated X-linked retinitis pigmentosa’
- Cristina Martinez-Fernandez de la Camara, Jasmina Cehajic-Kapetanovic, Robert E MacLaren, …, Cristina Martinez-Fernandez de la Camara, Jasmina Cehajic-Kapetanovic, Robert E MacLaren
- Expert Opin Emerg Drugs, 10.1080/14728214.2022.2152212
A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging
- Tibor Kovács, Janka Szinyákovics, Viktor Billes, …, Károly Gulya, Zsófia Maglóczky, Tibor Vellai
- Sci Rep, 10.1038/s41598-022-24843-w
Identification and characterization of Necdin as a target for the Cockayne syndrome B protein in promoting neuronal differentiation and maintenance
- Fangkeng Liang, Bijuan Li, Yingying Xu, …, Shaohui Zheng, Yunlong Zhang, Yuming Wang
- Pharmacol Res, 10.1016/j.phrs.2022.106637
PRPH2-Associated Retinopathy: Novel Variants and Genotype-Phenotype Correlations
- Lorenzo Bianco, Alessandro Arrigo, Alessio Antropoli, …, Francesco Bandello, Paola Carrera, Maurizio Battaglia Parodi
- Ophthalmol Retina, 10.1016/j.oret.2022.12.008
GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans
- Jieyu Wu, Liuyang Wang, John F Ervin, …, Erik Soderblom, Dennis Ko, Dong Yan
- Sci Adv, 10.1126/sciadv.adc9236
Advances in amyotrophic lateral sclerosis research in 2022
- Mamede de Carvalho, Mamede de Carvalho, Mamede de Carvalho
- Lancet Neurol, 10.1016/s1474-4422(22)00490-2
FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50
- Gozde Inci, Madhuri Shende Warkad, Beom-Goo Kang, …, Jaebong Kim, Sung-Chan Kim, Jae-Yong Lee
- Molecules, 10.3390/molecules27238623