Channel: Gene regulatory network

A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell. Wikipedia (CC BY-SA 3.0)

2023 Articles

21 703 articles

Predicting the behavior of cerebral aneurysms, a different approach is necessary

  • Saleha Azeem, Mohsin Rashid, Zaid Aljuboori, Saleha Azeem, Mohsin Rashid, Zaid Aljuboori
  • None, 10.25259/sni_1035_2022
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An oracle predicts regulators of cell identity

  • Jeffrey A Farrell, Jeffrey A Farrell, Jeffrey A Farrell, Jeffrey A Farrell, Jeffrey A Farrell
  • Nature, 10.1038/d41586-023-00251-6
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wpLogicNet: logic gate and structure inference in gene regulatory networks

  • Seyed Amir Malekpour, Maryam Shahdoust, Rosa Aghdam, …, Maryam Shahdoust, Rosa Aghdam, Mehdi Sadeghi
  • Bioinformatics, 10.1093/bioinformatics/btad072
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EnsInfer: a simple ensemble approach to network inference outperforms any single method

  • Bingran Shen, Gloria Coruzzi, Dennis Shasha, …, Bingran Shen, Gloria Coruzzi, Dennis Shasha
  • BMC Bioinformatics, 10.1186/s12859-023-05231-1
Comment Section

Sensitivity Analysis of Genome-Scale Metabolic Flux Prediction

  • Puhua Niu, Maria J Soto, Shuai Huang, …, Francis J Alexander, Ian Blaby, Xiaoning Qian
  • J Comput Biol, 10.1089/cmb.2022.0368
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kboolnet: a toolkit for the verification, validation, and visualization of reaction-contingency (rxncon) models

  • Willow Carretero Chavez, Marcus Krantz, Edda Klipp, …, Marcus Krantz, Edda Klipp, Irina Kufareva
  • BMC Bioinformatics, 10.1186/s12859-023-05329-6
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Multiscale computational modeling offers key to understanding molecular logic underpinning development and disease

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MCPNet: a parallel maximum capacity-based genome-scale gene network construction framework

  • Tony Pan, Sriram P Chockalingam, Maneesha Aluru, …, Sriram P Chockalingam, Maneesha Aluru, Srinivas Aluru
  • Bioinformatics, 10.1093/bioinformatics/btad373
Comment Section

Inferring gene regulatory networks using transcriptional profiles as dynamical attractors

  • Ruihao Li, Jordan C Rozum, Morgan M Quail, …, Clarissa J Nobile, Réka Albert, Aaron D Hernday
  • PLoS Comput Biol, 10.1371/journal.pcbi.1010991
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2022 Articles

2 223 articles

Accurate determination of causalities in gene regulatory networks by dissecting downstream target genes

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REFINING CELLULAR PATHWAY MODELS USING AN ENSEMBLE OF HETEROGENEOUS DATA SOURCES

  • Alexander M Franks, Florian Markowetz, Edoardo M Airoldi, …, Alexander M Franks, Florian Markowetz, Edoardo M Airoldi
  • None, 10.1214/16-aoas915
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NetSHy: network summarization via a hybrid approach leveraging topological properties

  • Thao Vu, Elizabeth M Litkowski, Weixuan Liu, …, Russell P Bowler, Farnoush Banaei-Kashani, Katerina J Kechris
  • Bioinformatics, 10.1093/bioinformatics/btac818
Comment Section

Functional Resilience of Mutually Repressing Motifs Embedded in Larger Networks

  • Pradyumna Harlapur, Atchuta Srinivas Duddu, Kishore Hari, …, Kishore Hari, Prakash Kulkarni, Mohit Kumar Jolly
  • Biomolecules, 10.3390/biom12121842
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Inference of regulatory networks through temporally sparse data

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Inferring gene regulatory networks from single-cell gene expression data via deep multi-view contrastive learning

  • Zerun Lin, Le Ou-Yang, Zerun Lin, …, Le Ou-Yang, Zerun Lin, Le Ou-Yang
  • Brief Bioinform, 10.1093/bib/bbac586
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A generic parallel framework for inferring large-scale gene regulatory networks from expression profiles: application to Alzheimer’s disease network

  • Softya Sebastian, Swarup Roy, Jugal Kalita, …, Softya Sebastian, Swarup Roy, Jugal Kalita
  • Brief Bioinform, 10.1093/bib/bbac482
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Leveraging class hierarchy for detecting missing annotations on hierarchical multi-label classification

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Systematic comparison of modeling fidelity levels and parameter inference settings applied to negative feedback gene regulation

  • Adrien Coulier, Prashant Singh, Marc Sturrock, …, Prashant Singh, Marc Sturrock, Andreas Hellander
  • PLoS Comput Biol, 10.1371/journal.pcbi.1010683
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A Comparison of Weighted Stochastic Simulation Methods for the Analysis of Genetic Circuits

  • Mohammad Ahmadi, Payton J Thomas, Lukas Buecherl, …, Chris Winstead, Chris J Myers, Hao Zheng
  • ACS Synth Biol, 10.1021/acssynbio.2c00553
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