CRISPR gene editing (pronounced /ˈkrɪspər/ "crisper") is a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified. It is based on a simplified version of the bacterial CRISPR-Cas9 antiviral defense system. By delivering the Cas9 nuclease complexed with a synthetic guide RNA (gRNA) into a cell, the cell's genome can be cut at a desired location, allowing existing genes to be removed and/or new ones added in vivo. Wikipedia (CC BY-SA 3.0)
2023 Articles
22 555 articles
Pasting in large DNA sequences
- Sarah Crunkhorn, Sarah Crunkhorn, Sarah Crunkhorn, …, Sarah Crunkhorn, Sarah Crunkhorn, Sarah Crunkhorn
- Nat Rev Drug Discov, 10.1038/d41573-023-00011-1
CRISPR base editing protects the heart
- Alex Eccleston, Alex Eccleston, Alex Eccleston, Alex Eccleston, Alex Eccleston
- Nat Rev Drug Discov, 10.1038/d41573-023-00018-8
Editorial: CRISPR and beyond: Cutting-edge technologies for gene correction in therapeutic applications
- Ayal Hendel, Rasmus O Bak, Ayal Hendel, Rasmus O Bak
- None, 10.3389/fgeed.2023.1203864
Author Correction: Voyage to minimal base editors
- Beomjong Song, Beomjong Song, Sangsu Bae
- Nat Chem Biol, 10.1038/s41589-023-01266-w
Base editing of CaMKIIδ shows promise as cardiac therapy
- Irene Fernández-Ruiz, Irene Fernández-Ruiz, Irene Fernández-Ruiz, Irene Fernández-Ruiz, Irene Fernández-Ruiz, Irene Fernández-Ruiz
- Nat Rev Cardiol, 10.1038/s41569-023-00838-6
Editing for the pulp market
- Philip Ball, Philip Ball
- Nat Mater, 10.1038/s41563-023-01634-w
Precise insertions of large DNA fragments for cell and gene therapy
- Guanglei Li, Qi Zhang, Tingbo Liang, …, Qi Zhang, Tingbo Liang, Xingxu Huang
- Sci Bull (Beijing), 10.1016/j.scib.2023.04.013
CRISPR Milestones for Sustainable Agriculture and Forestry
- Rodolphe Barrangou, Rodolphe Barrangou, Rodolphe Barrangou
- CRISPR J, 10.1089/crispr.2023.29163.editorial
Regulation of adipose tissue development and energy metabolism by VEGFB isoforms
- Yang Chen, Xin Li, Jing Zhang, …, Xuechao Feng, Luqing Zhang, Yaowu Zheng
- J Endocrinol, 10.1530/joe-22-0329
Explaining the male bias in cancers
- Michael Attwaters
- Nat Rev Genet, 10.1038/s41576-023-00650-5
2022 Articles
2 072 articles
Human vaccines & immunotherapeutics: News November 2022
- Ronald Ellis, Adam Weiss, Ronald Ellis, …, Adam Weiss, Ronald Ellis, Adam Weiss
- Hum Vaccin Immunother, 10.1080/21645515.2022.2155378
Improved genome editing by an engineered CRISPR-Cas12a
- Enbo Ma, Kai Chen, Honglue Shi, …, Kaihong Zhou, Jinjuan Ye, Jennifer A Doudna
- Nucleic Acids Res, 10.1093/nar/gkac1192
A Decade of CRISPR-Cas Gnome Editing in C. elegans
- Hyun-Min Kim, Yebin Hong, Jiani Chen, …, Hyun-Min Kim, Yebin Hong, Jiani Chen
- Int J Mol Sci, 10.3390/ijms232415863
Circular Guide RNA for Improved Stability and CRISPR-Cas9 Editing Efficiency in Vitro and in Bacteria
- Li Liu, Wenbo Li, Ju Li, …, Xuxu Chen, Changhao Bi, Xueli Zhang
- ACS Synth Biol, 10.1021/acssynbio.2c00381
Breast cancer: recent advances in molecular approaches
- Yanjie Shen, Deyu Zhang, Qinong Ye, …, Yanjie Shen, Deyu Zhang, Qinong Ye
- Sci Bull (Beijing), 10.1016/j.scib.2022.03.003
TAPE-seq is a cell-based method for predicting genome-wide off-target effects of prime editor
- Jeonghun Kwon, Minyoung Kim, Seungmin Bae, …, Anna Jo, Youngho Kim, Jungjoon K Lee
- Nat Commun, 10.1038/s41467-022-35743-y
Construction and evaluation of gRNA arrays for multiplex CRISPR-Cas9
- Gašper Žun, Katja Doberšek, Uroš Petrovič, …, Gašper Žun, Katja Doberšek, Uroš Petrovič
- Yeast, 10.1002/yea.3833
Introduction of the FecGF mutation in GDF9 gene via CRISPR/Cas9 system with single-stranded oligodeoxynucleotide
- Xin Xu, Xuemei Zhang, Xinrong Peng, …, Chunjie Liu, Wenrong Li, Mingjun Liu
- Theriogenology, 10.1016/j.theriogenology.2022.11.044
Prime Editing in Mammals: The Next Generation of Precision Genome Editing
- Dawei Wang, Xiude Fan, Mengzhu Li, …, Yuan Li, JunMing Han, JiaJun Zhao
- CRISPR J, 10.1089/crispr.2022.0084
Miniature CRISPR-Cas12f1-Mediated Single-Nucleotide Microbial Genome Editing Using 3′-Truncated sgRNA
- Ho Joung Lee, Hyun Ju Kim, Sang Jun Lee, …, Ho Joung Lee, Hyun Ju Kim, Sang Jun Lee
- CRISPR J, 10.1089/crispr.2022.0071