Chromosome segregation is the process in eukaryotes by which two sister chromatids formed as a consequence of DNA replication, or paired homologous chromosomes, separate from each other and migrate to opposite poles of the nucleus. This segregation process occurs during both mitosis and meiosis. Chromosome segregation also occurs in prokaryotes. However, in contrast to eukaryotic chromosome segregation, replication and segregation are not temporally separated. Instead segregation occurs progressively following replication. Wikipedia (CC BY-SA 3.0)
2023 Articles
142 articles
Structural basis of centromeric cohesion protection
- Alberto García-Nieto, Amrita Patel, Yan Li, …, Kyle W Muir, Daniel Panne, Benjamin D Rowland
- Nat Struct Mol Biol, 10.1038/s41594-023-00968-y
BiFCo: visualizing cohesin assembly/disassembly cycle in living cells
- Emilio González-Martín, Emilio González-Martín, Emilio González-Martín, …, Emilio González-Martín, Juan Jiménez, Víctor A Tallada
- Life Sci Alliance, 10.26508/lsa.202301945
Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase
- Paul Batty, Christoph Ch Langer, Zsuzsanna Takács, …, Claudia Blaukopf, Jan-Michael Peters, Daniel W Gerlich
- EMBO J, 10.15252/embj.2023113475
Genome control by SMC complexes
- Claire Hoencamp, Claire Hoencamp, Claire Hoencamp, Claire Hoencamp, Benjamin D Rowland
- Nat Rev Mol Cell Biol, 10.1038/s41580-023-00609-8
The material properties of mitotic chromosomes
- Maximilian F D Spicer, Daniel W Gerlich, Maximilian F D Spicer, …, Daniel W Gerlich, Maximilian F D Spicer, Daniel W Gerlich
- Curr Opin Struct Biol, 10.1016/j.sbi.2023.102617
Separase and Roads to Disengage Sister Chromatids during Anaphase
- Marketa Konecna, Soodabeh Abbasi Sani, Martin Anger, …, Marketa Konecna, Soodabeh Abbasi Sani, Martin Anger
- Int J Mol Sci, 10.3390/ijms24054604
ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells
- Zhouliang Yu, Hyung Jun Kim, Zhouliang Yu, …, Zhouliang Yu, Hyung Jun Kim, Abby F Dernburg
- Nat Struct Mol Biol, 10.1038/s41594-023-00929-5
Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation
- Sanjana Sundararajan, Hyewon Park, Shinji Kawano, …, Daniel Keifenheim, Duncan J Clarke, Yoshiaki Azuma
- None, 10.1016/j.isci.2023.106743
The histone methyltransferase NSD3 contributes to sister chromatid cohesion and to cohesin loading at mitotic exit
- Grégory Eot-Houllier, Laura Magnaghi-Jaulin, Gaëlle Bourgine, …, Régis Giet, Erwan Watrin, Christian Jaulin
- J Cell Sci, 10.1242/jcs.261014
Cornelia de Lange Syndrome mutations in SMC1A cause cohesion defects in yeast
- Jingrong Chen, Erin N Floyd, Dean S Dawson, Susannah Rankin
- Genetics, 10.1093/genetics/iyad159
2022 Articles
9 articles
Connections between sister and non-sister telomeres of segregating chromatids maintain euploidy
- Brandt Warecki, Ian Bast, Matthew Tajima, …, Ian Bast, Matthew Tajima, William Sullivan
- Curr Biol, 10.1016/j.cub.2022.11.038
Selective utilization of non-homologous end-joining and homologous recombination for DNA repair during meiotic maturation in mouse oocytes
- Crystal Lee, Jiyeon Leem, Jeong Su Oh, …, Crystal Lee, Jiyeon Leem, Jeong Su Oh
- Cell Prolif, 10.1111/cpr.13384
Cyclins and CDKs in the regulation of meiosis-specific events
- Inés Palacios-Blanco, Cristina Martín-Castellanos, Inés Palacios-Blanco, Cristina Martín-Castellanos
- None, 10.3389/fcell.2022.1069064
The CMG helicase and cancer: a tumor “engine” and weakness with missing mutations
- Shengyan Xiang, Shengyan Xiang, Shengyan Xiang, …, Shengyan Xiang, Damon R Reed, Mark G Alexandrow
- Oncogene, 10.1038/s41388-022-02572-8
OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse
- Shinichi Hayashi, Souichi Oe, Taro Koike, …, Yoshiki Yasukochi, Koichiro Higasa, Masaaki Kitada
- J Neurochem, 10.1111/jnc.15746
Rad51-mediated interhomolog recombination during budding yeast meiosis is promoted by the meiotic recombination checkpoint and the conserved Pif1 helicase
- Andrew Ziesel, Qixuan Weng, Jasvinder S Ahuja, …, G Valentin Börner, Michael Lichten, Nancy M Hollingsworth
- PLoS Genet, 10.1371/journal.pgen.1010407
Targets of histone H3 lysine 9 methyltransferases
- Aidan J Levinsky, Gregor McEdwards, Nasha Sethna, …, Gregor McEdwards, Nasha Sethna, Mark A Currie
- None, 10.3389/fcell.2022.1026406
Increased replication origin firing links replication stress to whole chromosomal instability in human cancer
- Nicolas Böhly, Ann-Kathrin Schmidt, Xiaoxiao Zhang, …, Magdalena Hennecke, Maik Kschischo, Holger Bastians
- Cell Rep, 10.1016/j.celrep.2022.111836
Integrating extrusion complex-associated pattern to predict cell type-specific long-range chromatin loops
- Yajing Deng, Li Tang, Xiaolong Zhou, …, Xiaolong Zhou, Wenkang Wang, Min Li
- None, 10.1016/j.isci.2022.105687