Inspired by: Aled Edwards
Chemical probes are small molecules that can modulate a biological process in a specific and measurable way. These probes are vital tools in chemical biology, pharmacology, and drug discovery because they can help elucidate the roles of specific proteins or other targets in health and disease. ChatGPT (CC BY 4.0)
2023 Articles
37 445 articles
Genomic surveillance of SARS-CoV-2 upsurge in India due to Omicron sub-lineages BA.2.74, BA.2.75 and BA.2.76
- Urvashi B Singh, Sushanta Deb, Lata Rani, …, Rama Chaudhry, Subrata Sinha, Randeep Guleria
- None, 10.1016/j.lansea.2023.100148
A chemical strategy to study transient states in substrate ubiquitylation by cryo-EM
- Qi Hu, Maria Victoria Botuyan, Georges Mer, Qi Hu, Maria Victoria Botuyan, Georges Mer
- None, 10.1016/j.chempr.2023.04.016
Effect of Conformational Variability on Seasonable Thermal Stability and Cell Entry of Omicron Variants
- Hiroshi Izumi, Hiroshi Aoki, Laurence A Nafie, …, Hiroshi Aoki, Laurence A Nafie, Rina K Dukor
- None, 10.1021/acsomega.2c08075
Structural biology at the scale of proteomes
- Nazim Bouatta, Mohammed AlQuraishi, Nazim Bouatta, …, Mohammed AlQuraishi, Nazim Bouatta, Mohammed AlQuraishi
- Nat Struct Mol Biol, 10.1038/s41594-023-00924-w
2B or not 2B: art thou autoinhibitory?
- Thomas A J McKinnon, Thomas A J McKinnon, Thomas A J McKinnon, Thomas A J McKinnon
- Blood, 10.1182/blood.2022019577
Robust Design of Effective Allosteric Activators for Rsp5 E3 Ligase Using the Machine Learning Tool ProteinMPNN
- Hsi-Wen Kao, Wei-Lin Lu, Meng-Ru Ho, …, Tzu-Ping Ko, Shang-Te Danny Hsu, Kuen-Phon Wu
- ACS Synth Biol, 10.1021/acssynbio.3c00042
Visualizing and accessing correlated SAXS data sets with Similarity Maps and Simple Scattering web resources
- Daniel T Murray, David S Shin, Scott Classen, …, Scott Classen, Chris A Brosey, Greg L Hura
- Methods Enzymol, 10.1016/bs.mie.2022.09.024
MineProt: a stand-alone server for structural proteome curation
- Yunchi Zhu, Chengda Tong, Zuohan Zhao, …, Chengda Tong, Zuohan Zhao, Zuhong Lu
- Database (Oxford), 10.1093/database/baad059
Likelihood-based docking of models into cryo-EM maps
- Claudia Millán, Airlie J McCoy, Thomas C Terwilliger, …, Airlie J McCoy, Thomas C Terwilliger, Randy J Read
- Acta Crystallogr D Struct Biol, 10.1107/s2059798323001602
Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties
- Davide Sala, Peter W Hildebrand, Jens Meiler, Davide Sala, Peter W Hildebrand, Jens Meiler
- None, 10.3389/fmolb.2023.1121962
2022 Articles
3 821 articles
Ranking Peptide Binders by Affinity with AlphaFold
- Liwei Chang, Alberto Perez, Liwei Chang, …, Alberto Perez, Liwei Chang, Alberto Perez
- Angew Chem Int Ed Engl, 10.1002/anie.202213362
Crystal Structure of l-2,4-Diketo-3-deoxyrhamnonate Hydrolase Involved in the Nonphosphorylated l-Rhamnose Pathway from Bacteria
- Shota Fukuhara, Seiya Watanabe, Yasunori Watanabe, …, Seiya Watanabe, Yasunori Watanabe, Hisashi Nishiwaki
- Biochemistry, 10.1021/acs.biochem.2c00596
State-of-the-Art Estimation of Protein Model Accuracy Using AlphaFold
- James P Roney, Sergey Ovchinnikov, James P Roney, Sergey Ovchinnikov, James P Roney, Sergey Ovchinnikov
- Phys Rev Lett, 10.1103/physrevlett.129.238101
Ratchet, swivel, tilt and roll: a complete description of subunit rotation in the ribosome
- Asem Hassan, Sandra Byju, Frederico Campos Freitas, …, Ronaldo Junio de Oliveira, Christine M Dunham, Paul C Whitford
- Nucleic Acids Res, 10.1093/nar/gkac1211
Mechanisms of DNA opening revealed in AAA+ transcription complex structures
- Fuzhou Ye, Forson Gao, Xiaojiao Liu, …, Xiaojiao Liu, Martin Buck, Xiaodong Zhang
- Sci Adv, 10.1126/sciadv.add3479
Structural Insights into the Dimeric Form of Bacillus subtilis RNase Y Using NMR and AlphaFold
- Nelly Morellet, Pierre Hardouin, Nadine Assrir, …, Nadine Assrir, Carine van Heijenoort, Béatrice Golinelli-Pimpaneau
- Biomolecules, 10.3390/biom12121798
Csk αC Helix: A Computational Analysis of an Essential Region for Conformational Transitions
- Raphael Vinicius Rodrigues Dias, Carolina Tatiani Alves Ferreira, Patricia Ann Jennings, …, Patricia Ann Jennings, Paul Charles Whitford, Leandro Cristante de Oliveira
- J Phys Chem B, 10.1021/acs.jpcb.2c05408
Cryo-EM structure of the diapause chaperone artemin
- Amar D Parvate, Samantha M Powell, Jory T Brookreson, …, Irina V Novikova, Mowei Zhou, James E Evans
- None, 10.3389/fmolb.2022.998562
The nematode α-catenin ortholog, HMP1, has an extended α-helix when bound to actin filaments
- Erumbi S Rangarajan, Emmanuel W Smith, Tina Izard, …, Erumbi S Rangarajan, Emmanuel W Smith, Tina Izard
- J Biol Chem, 10.1016/j.jbc.2022.102817
A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway
- Emily B Lancaster, William H Johnson, Jake A LeVieux, …, Haley A Hardtke, Yan Jessie Zhang, Christian P Whitman
- Arch Biochem Biophys, 10.1016/j.abb.2022.109471