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2023 Articles
1 034 articles
Clonal differences underlie variable responses to sequential and prolonged treatment
- Dylan L Schaff, Aria J Fasse, Phoebe E White, Robert J Vander Velde, Sydney M Shaffer
- bioRxiv : the preprint server for biology, 10.1101/2023.03.24.534152
Cell-to-cell variability in Myc dynamics drives transcriptional heterogeneity in cancer cells
- Chad Liu, Takamasa Kudo, Xin Ye, Karen Gascoigne
- Cell Rep, 10.1016/j.celrep.2023.112401
A novel integrated approach to predicting cancer immunotherapy efficacy
- Ruihan Luo, Jacqueline Chyr, Jianguo Wen, …, Yanfei Wang, Weiling Zhao, Xiaobo Zhou
- Oncogene, 10.1038/s41388-023-02670-1
Single-Nucleus Transcriptome Profiling of Locally Advanced Cervical Squamous Cell Cancer Identifies Neural-Like Progenitor Program Associated with the Efficacy of Radiotherapy
- Lei Zhang, Jun Ma, Di Zhou, …, Yongrui Bai, Haiyan Chen, Ying Jing
- Adv Sci (Weinh), 10.1002/advs.202300348
Stratification of non-small cell lung adenocarcinoma patients with EGFR actionable mutations based on drug-resistant stem cell genes
- Xiaohong Xie, Lifeng Li, Liang Xie, …, Xuefeng Xia, Zhiyi He, Chengzhi Zhou
- None, 10.1016/j.isci.2023.106584
Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions
- Keisuke Sugita, Iichiroh Onishi, Ran Nakayama, …, David A Largaespada, Masanobu Kitagawa, Morito Kurata
- Commun Biol, 10.1038/s42003-023-04941-9
Single-cell trajectory analysis reveals a CD9 positive state to contribute to exit from stem cell-like and embryonic diapause states and transit to drug-resistant states
- Alfonso Poire, Kang Jin Jeong, Dong Zhang, …, Gang Chen, Chaoyang Sun, Gordon B Mills
- Cell Death Dis, 10.1038/s41420-023-01586-9
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells
- Gianna T Busch, Maalavika Pillai, Jingxin Li, …, Jennifer A Wargo, Meenhard Herlyn, Arjun Raj
- Nature, 10.1038/s41586-023-06342-8
Single-cell transcriptomics dissects epithelial heterogeneity in HPV+ cervical adenocarcinoma
- Cong Wang, Lei Li, Fuhao Wang, …, Feng Geng, Jinbo Yue, Chao Liu
- J Med Virol, 10.1002/jmv.28480
A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers
- David Wang, Mathieu Quesnel-Vallieres, San Jewell, …, Kristen Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash
- Nat Commun, 10.1038/s41467-022-35369-0
2022 Articles
95 articles
Single-Cell Analysis Reveals Transcriptomic Features of Drug-Tolerant Persisters and Stromal Adaptation in a Patient-Derived EGFR-Mutated Lung Adenocarcinoma Xenograft Model
- Nadeem Moghal, Quan Li, Erin L Stewart, …, Frances A Shepherd, Geoffrey Liu, Ming-Sound Tsao
- J Thorac Oncol, 10.1016/j.jtho.2022.12.003
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies
- Sophia A Wild, Ian G Cannell, Ashley Nicholls, …, Dario Bressan, Gregory J Hannon, Kirsty Sawicka
- Elife, 10.7554/elife.80981
The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells
- Matthew J Martin, Derek B Oien, Aparna Gorthi, …, Lisa Drew, Yi Yao, Paul D Smith
- None, 10.1038/s41698-022-00337-w
PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
- Li-Li Long, Si-Cong Ma, Ze-Qin Guo, …, De-Hua Wu, Xue Bai, Zhong-Yi Dong
- Cancer Res, 10.1158/0008-5472.can-22-1740
Targeting cancer drug resistance utilizing organoid technology
- Changpeng Chai, Pengfei Ji, Hao Xu, …, Zhengfeng Wang, Hui Zhang, Wence Zhou
- Biomed Pharmacother, 10.1016/j.biopha.2022.114098
Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes
- Do Young Hyeon, Dowoon Nam, Youngmin Han, …, Jin-Young Jang, Daehee Hwang, Sang-Won Lee
- Nat Cancer, 10.1038/s43018-022-00479-7
Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis
- Susana Garcia-Recio, Toshinori Hinoue, Gregory L Wheeler, …, Elaine R Mardis, Tari A King, Charles M Perou
- Nat Cancer, 10.1038/s43018-022-00491-x
The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
- Harald Schuhwerk, Julia Kleemann, Pooja Gupta, …, Marc P Stemmler, Simone Brabletz, Thomas Brabletz
- Cell Rep, 10.1016/j.celrep.2022.111819
Genomic heterogeneity in pancreatic cancer organoids and its stability with culture
- Olalekan H Usman, Liting Zhang, Gengqiang Xie, …, Yue Julia Wang, Xian Mallory, Jerome Irianto
- None, 10.1038/s41525-022-00342-9
[Molecular markers of neuro-oncogenesis in patients with glioblastoma]
- A M Kopylov, O A Antipova, G V Pavlova, …, A M Kopylov, O A Antipova, G V Pavlova
- Zh Vopr Neirokhir Im N N Burdenko, 10.17116/neiro20228606199