Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, and is the cause of 60ā70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. Wikipedia (CC BY-SA 3.0)
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2023 Articles
13 124 articles
Gut microbes modulate neurodegeneration
- Tanya Jain, Yue-Ming Li, Tanya Jain, …, Yue-Ming Li, Tanya Jain, Yue-Ming Li
- Science, 10.1126/science.adf9548
When Alzheimer’s is LATE: Why Does it Matter?
- Peter T Nelson, Julie A Schneider, Gregory A Jicha, …, Gregory A Jicha, Michael Tran Duong, David A Wolk
- Ann Neurol, 10.1002/ana.26711
Precision diagnosis and staging of TDP-43 proteinopathies: harnessing the power of artificial intelligence
- Richard A Hickman, Sonja W Scholz, Richard A Hickman, …, Sonja W Scholz, Richard A Hickman, Sonja W Scholz
- Brain, 10.1093/brain/awad175
Reeling from news that reelin defends the brain against Alzheimer’s
- Edmond N Mouofo, Tara L Spires-Jones, Edmond N Mouofo, …, Tara L Spires-Jones, Edmond N Mouofo, Tara L Spires-Jones
- Cell Rep Med, 10.1016/j.xcrm.2023.101111
The complex genetic architecture of Alzheimer’s disease: novel insights and future directions
- Shea J Andrews, Alan E Renton, Brian Fulton-Howard, …, Anna Podlesny-Drabiniok, Edoardo Marcora, Alison M Goate
- EBioMedicine, 10.1016/j.ebiom.2023.104511
The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration
- Jamie M Walker, William Goette, Kurt Farrell, …, Charles L White, John F Crary, Timothy E Richardson
- Alzheimers Dement, 10.1002/alz.12966
Towards Improved Clinical Diagnosis of Argyrophilic Grain Disease Using Brain Imaging
- Shinobu Kawakatsu, Ryota Kobayashi, Shinobu Kawakatsu, …, Ryota Kobayashi, Shinobu Kawakatsu, Ryota Kobayashi
- J Alzheimers Dis, 10.3233/jad-230247
Emerging diagnostics and therapeutics for Alzheimer disease
- Wade K Self, David M Holtzman
- Nat Med, 10.1038/s41591-023-02505-2
Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
- Aya Murakami, Alexandra I Soto-Beasley, Ronald L Walton, …, Keith A Josephs, Owen A Ross, Dennis W Dickson
- Acta Neuropathol Commun, 10.1186/s40478-023-01611-z
Cross-Ī² helical filaments of Tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia
- Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, …, Ruben Vidal, Bernardino Ghetti, Wen Jiang
- Acta Neuropathol, 10.1007/s00401-023-02563-3
2022 Articles
1 464 articles
LATE-NC staging in routine neuropathologic diagnosis: an update
- Peter T Nelson, Edward B Lee, Matthew D Cykowski, …, Julie A Schneider, Dennis W Dickson, Manuela Neumann
- Acta Neuropathol, 10.1007/s00401-022-02524-2
Riluzole is associated with decreasing neuritic plaque severity in amyotrophic lateral sclerosis
- Srestha Mazumder, Heather McCann, Susan D’Silva, …, Dominic B Rowe, Matthew C Kiernan, Rachel H Tan
- Brain, 10.1093/brain/awac467
TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
- Yuichi Riku, Mari Yoshida, Yasushi Iwasaki, …, Gen Sobue, Masahisa Katsuno, Shinsuke Ishigaki
- Int J Mol Sci, 10.3390/ijms232415755
The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals
- Jamie M Walker, Shiva Kazempour Dehkordi, Jeff Schaffert, …, Charles L White Iii, Timothy E Richardson, Habil Zare
- J Alzheimers Dis, 10.3233/jad-220898
Granulovacuolar degeneration bodies are independently induced by tau and Ī±-synuclein pathology
- Marta Jorge-Oliva, Jasper F M Smits, Vera I Wiersma, …, Vera I Wiersma, Jeroen J M Hoozemans, Wiep Scheper
- Alzheimers Res Ther, 10.1186/s13195-022-01128-y
Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging
- Jolien Perneel, Manuela Neumann, Bavo Heeman, …, JĆŗlia Faura, Rosa Rademakers, Ian R A Mackenzie
- Acta Neuropathol, 10.1007/s00401-022-02531-3
Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer’s disease
- Etienne Aumont, Cyntia Tremblay, StĆ©phanie Levert, …, David A Bennett, FrĆ©dĆ©ric Calon, Nicole Leclerc
- None, 10.3389/fnagi.2022.1038343
Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains
- Ling Wu, Sidharth S Madhavan, Christopher Tan, …, Sidharth S Madhavan, Christopher Tan, Bin Xu
- None, 10.3390/pathogens11121559
Alzheimer’s Disease Genetic Risk, Cognition, and Brain Aging in Midlife
- Willa D Brenowitz, Myriam Fornage, Lenore J Launer, …, Mohamad Habes, Christos Davatzikos, Kristine Yaffe
- Ann Neurol, 10.1002/ana.26569
AD and non-AD mediators of the pathway between the APOE genotype and cognition
- Emma Nichols, Adam M Brickman, Kaitlin B Casaletto, …, Julie Schneider, Judy Pa, Renaud La Joie
- Alzheimers Dement, 10.1002/alz.12885