Inspired by: ProQR Therapeutics
The double-stranded RNA-specific adenosine deaminase enzyme family are encoded by the ADAR family genes. ADAR stands for adenosine deaminase acting on RNA. This article focuses on the ADAR proteins; This article details the evolutionary history, structure, function, mechanisms and importance of all proteins within this family. Wikipedia (CC BY-SA 3.0)
2023 Articles
241 articles
ADAR1p150 Prevents MDA5 and PKR Activation via Distinct Mechanisms to Avert Fatal Autoinflammation
- Shi-Bin Hu, Jacki Heraud-Farlow, Tao Sun, …, Scott Taylor, Carl R Walkley, Jin Billy Li
- bioRxiv : the preprint server for biology, 10.1101/2023.01.25.525475
RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing
- Yanfang Xing, Taisuke Nakahama, Yuke Wu, …, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
- J Biol Chem, 10.1016/j.jbc.2023.104840
Emerging role of the RNA-editing enzyme ADAR1 in stem cell fate and function
- Di Lu, Jianxi Lu, Qiuli Liu, …, Jianxi Lu, Qiuli Liu, Qi Zhang
- None, 10.1186/s40364-023-00503-7
Library Screening Reveals Sequence Motifs That Enable ADAR2 Editing at Recalcitrant Sites
- Casey S Jacobsen, Prince Salvador, John F Yung, …, Herra G Mendoza, Gail Mandel, Peter A Beal
- ACS Chem Biol, 10.1021/acschembio.3c00107
Squid express conserved ADAR orthologs that possess novel features
- Isabel C Vallecillo-Viejo, Gjendine Voss, Caroline B Albertin, …, Noa Liscovitch-Brauer, Eli Eisenberg, Joshua J C Rosenthal
- None, 10.3389/fgeed.2023.1181713
Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?
- Julia-Sophia Bellingrath, Michelle E McClements, M Dominik Fischer, …, Michelle E McClements, M Dominik Fischer, Robert E MacLaren
- None, 10.3389/fnmol.2023.1092913
Transcriptome-wide profiling of A-to-I RNA editing by Slic-seq
- Qi Wei, Shaoqing Han, Kexin Yuan, …, Bifeng Yuan, Xiaocheng Weng, Xiang Zhou
- Nucleic Acids Res, 10.1093/nar/gkad604
Generation of a new Adar1p150 -/- mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis
- Zhen Liang, Ankita Goradia, Carl Walkley, …, Ankita Goradia, Carl R Walkley, Jacki E Heraud-Farlow
- RNA, 10.1261/rna.079509.122
Extensive Recoding of the Neural Proteome in Cephalopods by RNA Editing
- Joshua J C Rosenthal, Eli Eisenberg, Joshua J C Rosenthal, …, Eli Eisenberg, Joshua J C Rosenthal, Eli Eisenberg
- Annu Rev Anim Biosci, 10.1146/annurev-animal-060322-114534
Chemical Modifications in RNA: Elucidating the Chemistry of dsRNA-Specific Adenosine Deaminases (ADARs)
- Herra G Mendoza, Peter A Beal
- Acc Chem Res, 10.1021/acs.accounts.3c00390
2022 Articles
16 articles
ADAR1p110 promotes Enterovirus D68 replication through its deaminase domain and inhibition of PKR pathway
- Kehan Zhang, Siyuan Wang, Tingting Chen, …, Yong Cheng, Nan Lu, Guangyuan Zhang
- Virol J, 10.1186/s12985-022-01952-6
Altered RNA Editing in Atopic Dermatitis Highlights the Role of Double-Stranded RNA for Immune Surveillance
- Miriam Karmon, Eli Kopel, Aviv Barzilai, …, Eli Eisenberg, Erez Y Levanon, Shoshana Greenberger
- J Invest Dermatol, 10.1016/j.jid.2022.11.010
Recurrent RNA edits in human preimplantation potentially enhance maternal mRNA clearance
- Yang Ding, Yang Zheng, Junting Wang, …, Ge Gao, Hebing Chen, Xiaochen Bo
- Commun Biol, 10.1038/s42003-022-04338-0
RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
- Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, …, Pierre de la Grange, Peter T Nelson, Stefan Stamm
- Nucleic Acids Res, 10.1093/nar/gkac1129
ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
- Florian Szymczak, Roni Cohen-Fultheim, Sofia Thomaidou, …, Erez Levanon, Decio Eizirik, Arnaud Zaldumbide
- Front Endocrinol (Lausanne), 10.3389/fendo.2022.1058345
Proteomic Analysis of Zebrafish Protein Recoding via mRNA Editing by ADAR Enzymes
- Shamsudin S Nasaev, Anna S Kopeykina, Ksenia G Kuznetsova, …, Ksenia G Kuznetsova, Lev I Levitsky, Sergei A Moshkovskii
- Biochemistry (Mosc), 10.1134/s0006297922110098
ADAR1 promotes systemic sclerosis via modulating classic macrophage activation
- Chenming Sun, Dunpeng Cai, Shi-You Chen, …, Chenming Sun, Dunpeng Cai, Shi-You Chen
- Front Immunol, 10.3389/fimmu.2022.1051254
CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons
- Jinghui Song, Liting Dong, Hanxiao Sun, …, Ke Liu, Jiaxu Hong, Chengqi Yi
- Mol Cell, 10.1016/j.molcel.2022.11.011
ADAR1 improved Treg cell function through the miR-21b/Foxp3 axis and inhibits the progression of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
- Yanru Zhao, Xiaoyan Zheng, Miaojing Li, …, Jing Zhao, Xiaoning Wang, Huachao Zhu
- Int Immunopharmacol, 10.1016/j.intimp.2022.109620
Metabolic Analysis of Nucleosides/Bases in the Urine and Serum of Patients with Alcohol-Associated Liver Disease
- Liqing He, Vatsalya Vatsalya, Xipeng Ma, …, Wenke Feng, Craig J McClain, Xiang Zhang
- None, 10.3390/metabo12121187