A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity

Nature communications

Behrouz Eslami-Mossallam, Misha Klein, Constantijn V D Smagt, …, John A Hawkins, Ilya J Finkelstein, Martin Depken

• DOI: 10.1038/s41467-022-28994-2
• PMID: 35292641
• PMCID: PMC8924176