Arnold World June 2023

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Journal of the American Chemical Society

Mechanism and Dynamics of Photodecarboxylation Catalyzed by Lactate Monooxygenase.

2023-06-08

PubMed:37289179; DOI:10.1021/jacs.3c02446

Xiankun Li¹, Claire G Page¹, Laura Zanetti-Polzi², Aarat P Kalra¹, Daniel G Oblinsky¹, Isabella Daidone³, Todd K Hyster⁴, Gregory D Scholes¹

Affiliations

Department of Chemistry, Frick Laboratory, Princeton University, Princeton, New Jersey 08544, United States
Center S3, CNR-Institute of Nanoscience, Via Campi 213/A, Modena 41125, Italy
Department of Physical and Chemical Sciences, University of L’Aquila, via Vetoio (Coppito 1), L’Aquila 67010, Italy
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States

RRIDs were included in the Journal of the American Chemical Society paper “Mechanism and Dynamics of Photodecarboxylation Cat…” (https://doi.org/10.1021/jacs.3c02446…). Thank you for making your #methodsmatter. #accelerateopenscience

2023-07-12

Mechanism and Dynamics of Photodecarboxylation Catalyzed by Lactate Monooxygenase by Xiankun Li, @pagedclaire, Laura Zanetti-Polzi, @AaratKalra, Daniel Oblinsky, Isabella Daidone, Todd Hyster @HysterLab at @PrincetonChem, and Gregory D. Scholes in @J_A_C_S https://pubs.acs.org/doi/full/10.1021/jacs.3c02446…

2023-06-15

Angewandte Chemie (International ed. in English)

Reversing the Enantioselectivity of Enzymatic Carbene N-H Insertion Through Mechanism-Guided Protein Engineering.

2023-06-01

PubMed:37260412; DOI:10.1002/anie.202303879

Carla Calvó-Tusell¹, Zhen Liu², Kai Chen², Frances H Arnold², Marc Garcia-Borràs³

Affiliations

Universitat de Girona, Institut de Química Computacional i Catàlisi and Departament de Química, 17003, Girona, SPAIN
Caltech: California Institute of Technology, Division of Chemistry and Chemical Engineering, 1200 E California Blvd., 91125, Pasadena, UNITED STATES
Universitat de Girona, Institut de Química Computacional i Catàlisi and Departament de Química, Campus de Montilivi s/n, Facultat de Ciències, Girona, España, 17071, Girona, SPAIN

We reversed the carbene NH insertion enzyme selectivity through mechanism-guided protein engineering! This work is now published on Angewantehttps://onlinelibrary.wiley.com/doi/10.1002/anie.202303879… Huge congrats to @MarcGBQ @ccalvotusell @kaichen_1990 and @francesarnold

2023-06-03

kedalionlabs.com

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