Alonosphere May 2023

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bioRxiv

Pregnancy and postpartum dynamics revealed by an atlas of millions of lab tests

2023-05-14

DOI:10.1101/2023.05.11.540359

A. Bar, N. Mendelson Cohen, Y. Korem Kohanim, A. Mayo, Y. Toledano, U. Alon

Affiliations

Weizmann Institute of Science

11/ Read our preprint to explore the full details of our study and access the comprehensive dataset: https://biorxiv.org/content/10.1101/2023.05.11.540359v1…. #bioRxivPhysio #OpenData

2023-05-18

Dynamic atlas of 78 laboratory tests with weekly time resolution, spanning the period from 20 weeks pre-conception until 80 weeks postpartum, totaling 45 million measurements from over half a million pregnancies
SneakPeak at Cell: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4451671…
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2023-05-20

Incredible work describing an anonymized, publicly available dataset of laboratory results before, during, and after pregnancy by @AlonBar10 et al.

2023-05-18

In pregnancy’s embrace, systems entwine,
Physiological shifts, a rhythm divine,
Postpartum rebound, changes unfold,
Weekly tests reveal the story, untold.

A dynamic atlas, time’s intricate thread,
From pre-conception to postpartum’s spread,
Millions of data points, a scientific quest,
Unveiling pregnancy’s dance, at its best.

quant-bio-classic

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eLife

Principles for coding associative memories in a compact neural network.

2023-05-04

PubMed:37140557; DOI:10.7554/eLife.74434

Christian Pritz¹, Eyal Itskovits¹, Eduard Bokman¹, Rotem Ruach¹, Vladimir Gritsenko¹, Tal Nelken¹, Mai Menasherof¹, Aharon Azulay¹, Alon Zaslaver¹

Affiliations

Department of Genetics, Silberman Institute for Life Sciences, Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem, Israel

Check out the beautiful work by Christian Pritz from @zaslab and colleagues @itskov @RotemRuach a nd others not in Twitter.
http://elifesciences.org/articles/74434 http://doi.org/10.54/eLife. and the related insight article
https://elifesciences.org/articles/87861

2023-05-04

Here is the thread I promised for our new publication https://elifesciences.org/articles/74434.
We asked how memory components are encoded within individual neurons of the compact nervous system of C. elegans….

2023-05-09

Our lab’s new publication in @elife reveals how memory components are distributed among individual neurons. https://elifesciences.org/articles/74434
A tour de force effort led by the one and only Christian Pritz and other amazing lab members.

A thread unfolding the findings will follow tomorrow.

2023-05-08

Proceedings of the National Academy of Sciences of the United States of America

Carbon isotope fractionation by an ancestral rubisco suggests that biological proxies for CO 2 through geologic time should be reevaluated.

2023-05-08

PubMed:37155899; DOI:10.1073/pnas.2300466120

Renée Z Wang¹, Robert J Nichols², Albert K Liu³, Avi I Flamholz⁴, Juliana Artier⁵, Doug M Banda⁶, David F Savage², John M Eiler¹, Patrick M Shih³, Woodward W Fischer¹

Affiliations

Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720
Plant Biosystems Design, Lawrence Berkeley National Lab, Joint Bioenergy Institute, Emeryville, CA 94608
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125
Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720
Department of Plant Biology, University of California, Davis, CA 95616

Huge congrats to Renee Wang, @Nichols_NTA, @LabShih @SavageCatsOnly on our new paper. Was a great pleasure to be part of the complicating our interpretation of the multibillion year C-isotope record.

2023-05-08

bioRxiv

Excitable dynamics of flares and relapses in autoimmune diseases

2023-05-04

DOI:10.1101/2023.05.03.539265

Y. Lebel, T. Milo, A. Bar, A. Mayo, U. Alon

Affiliations

Weizmann Institute of Science

bioRxiv

Robust differentiation in a synthetic stem-cell circuit

2023-05-01

DOI:10.1101/2023.05.01.538905

D. S. Glass, A. Bren, E. Vaisbourd, A. Mayo, U. Alon

Affiliations

human-physiology

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EMBO molecular medicine

Comparison of tumor-informed and tumor-naïve sequencing assays for ctDNA detection in breast cancer.

2023-05-10

PubMed:37161793; DOI:10.15252/emmm.202216505

Angela Santonja¹, Wendy N Cooper¹, Matthew D Eldridge¹, Paul A W Edwards¹, James A Morris¹, Abigail R Edwards¹, Hui Zhao¹, Katrin Heider¹, Dominique-Laurent Couturier¹, Aadhitthya Vijayaraghavan¹, Paulius Mennea¹, Emma-Jane Ditter¹, Christopher G Smith¹, Chris Boursnell¹, Raquel Manzano García¹, Oscar M Rueda², Emma Beddowes¹, Heather Biggs³, Stephen-John Sammut¹, Nitzan Rosenfeld¹, Carlos Caldas¹, Jean E Abraham⁴, Davina Gale¹

Affiliations

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK
MRC Biostatistics Unit, University of Cambridge, Cambridge, UK
Department of Oncology, University of Cambridge, Cambridge, UK
Cancer Research UK Cambridge Centre, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK

Drs. Jean Abraham and Davina Gale’s team shows that ctDNA dynamics and tumor allele fractions were highly concordant when targeting different mutation types in serial blood samples from #BreastCancer patients undergoing treatment. @CRUK_CI
https://bit.ly/3LW10lN

2023-05-14

Comparison of tumor-informed and tumor-naïve sequencing assays for #ctDNA detection in #BreastCancer

By A. Santonja, W.N. Cooper, J.E. Abraham, D. Gale & colleagues

#LiquidBiopsies
Read #openaccess: https://doi.org/10.15252/emmm.202216505…

2023-05-12

PLoS biology

Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis.

2023-05-19

PubMed:37205711; DOI:10.1371/journal.pbio.3002124

Adi Egozi¹, Oluwabunmi Olaloye², Lael Werner³, Tatiana Silva², Blake McCourt², Richard W Pierce², Xiaojing An⁴, Fujing Wang⁴, Kong Chen⁴, Jordan S Pober⁵, Dror Shouval³, Shalev Itzkovitz¹, Liza Konnikova²

Affiliations

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America
Pediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital Sheba Medical Center Ramat Gan, Israel
Department of Medicine, University of Pittsburgh Medical Center Montefiore Hospital, Pittsburgh, Pennsylvania, United States of America
Program in Human and Translational Immunology, Yale School of Medicine, New Haven, Connecticut, United States of America

An amazing collaboration with @SItzkovitz led by @AdiEgozi and @BunmiOlaloye. One step closer to world without NEC. #NEC @YalePediatrics @YaleMed @WeizmannScience. #PLOSBiology: Single-cell atlas of the human neonatal small intestine affected by NEC

2023-05-20

bioRxiv

Functional and metagenomic level diversities of human gut symbiont-derived glycolipids

2023-05-23

DOI:10.1101/2023.05.23.541633

J.-S. Yoo, B. Goh, K. Heo, D.-J. Jung, W. Zheng, C. C. Lee, N. Geva-Zatorsky, M. Wu, S. B. Park, D. L. Kasper, S. F. Oh

Affiliations

Brigham and Women\\\’s Hospital

kedalionlabs.com

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