Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Nature

Evanna L Mills, Dylan G Ryan, Hiran A Prag, …, Richard C Hartley, Michael P Murphy, Luke A O’Neill

• DOI: 10.1038/nature25986
• PMID: 29590092
• PMCID: PMC6047741