RabLab February 2023

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Nature

Thrifty energy metabolism in solid tumours.

2023-02-01

PubMed:36725937; DOI:10.1038/d41586-023-00151-9

Affiliations

Great story!
Thrifty energy metabolism in solid tumours

2023-02-01

Nature chemical biology

Complex regulation in a Comamonas platform for diverse aromatic carbon metabolism.

2023-02-06

PubMed:36747056; DOI:10.1038/s41589-022-01237-7

Rebecca A Wilkes¹, Jacob Waldbauer², Austin Caroll³, Manuel Nieto-Domínguez⁴, Darren J Parker³, Lichun Zhang², Adam M Guss³, Ludmilla Aristilde⁵

Affiliations

Department of Biological and Environmental Engineering, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, USA
Department of the Geophysical Sciences, University of Chicago, Chicago, IL, USA
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark
Department of Biological and Environmental Engineering, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, USA.

It was so much fun to write a News & Views article for Nature Chemical Biology on great work published by Prof. Ludmilla Aristilde, Adam Guss et al. @nchembio
https://nature.com/articles/s41589-022-01237-7…

2023-02-06

Wow, this is very cool! Unraveling the details of pathways involved in the bacterial breakdown of plastics and plant cell wall polymers. Congrats to all!

2023-02-07

A bacterium that naturally processes #plastics and #lignin compounds? How does it work? Just published in @nchembio Nature Chem Bio, @AristildeLab research unravels mechanisms of #metabolism in a Comamonas species as platform for #carbon recycling. Link: https://rdcu.be/c403i

2023-02-06

Proceedings of the National Academy of Sciences of the United States of America

The SLC25A47 locus controls gluconeogenesis and energy expenditure.

2023-02-22

PubMed:36812201; DOI:10.1073/pnas.2216810120

Jin-Seon Yook¹, Zachary H Taxin¹, Bo Yuan², Satoshi Oikawa¹, Christopher Auger¹, Beste Mutlu³, Pere Puigserver³, Sheng Hui², Shingo Kajimura¹

Affiliations

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115
Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115
Department of Cell Biology, Harvard Medical School, Boston, MA 02115

Phenotypes of mice with depletion of SLC25A47 include reduced mitochondrial pyruvate flux and hepatic gluconeogenesis, increased FGF21 and energy expenditure, providing a liver-specific target for restriction of hepatic gluconeogenesis #diabetes @PNASNews

2023-02-22

Most mitochondrial carriers are ubiquitously expressed, but two exceptions: UCP1 specific to brown fat, and an orphan carrier SLC25A47 to the liver. We found that this liver-specific carrier is required for hepatic gluconeogenesis and energy expenditure!

2023-02-22

microbes

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Metabolic engineering communications

Metabolic engineering of low-pH-tolerant non-model yeast, Issatchenkia orientalis , for production of citramalate.

2023-02-16

PubMed:36860699; DOI:10.1016/j.mec.2023.e00220

Zong-Yen Wu¹, Wan Sun², Yihui Shen³, Jimmy Pratas³, Patrick F Suthers⁴, Ping-Hung Hsieh⁵, Sudharsan Dwaraknath⁵, Joshua D Rabinowitz³, Costas D Maranas⁴, Zengyi Shao², Yasuo Yoshikuni¹

Affiliations

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA
Interdepartmental Microbiology Program, Iowa State University, Ames, IA, 50011-1027, USA
Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA
US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA

cancer-and-disease

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Redox biology

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis.

2023-02-09

PubMed:36841051; DOI:10.1016/j.redox.2023.102627

Didem Ilter¹, Stanislav Drapela¹, Tanya Schild², Nathan P Ward³, Emma Adhikari⁴, Vivien Low⁵, John Asara⁶, Thordur Oskarsson¹, Eric K Lau⁴, Gina M DeNicola³, Melanie R McReynolds⁷, Ana P Gomes⁸

Affiliations

Department of Molecular Oncology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Department of Cancer Physiology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA
Department of Tumor Biology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA
Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA
Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA
Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA, USA; Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA
Department of Molecular Oncology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA.

congrats to the @lab_gomes !

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation esse…

2023-02-24

Featured today by @MSKLibrary: #NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for #breastcancer #metastasis: https://dx.doi.org/10.1016/j.redox.2023.102627…
@StanislavDrpel1 @ThordurOskarss2 @LabDeNicola @mcreynolds_lab @dr_ohsopretty

2023-03-13

“Here, we show that NADK is upregulated in metastatic breast cancer cells enabling de novo production of NADP(H) and the expansion of the NADP(H) pools thereby increasing the ability of these cells to adapt to the challenges of the metastatic cascade and efficiently metastasize”

2023-02-24

So excited to share the first original publication from our lab, where we explore an essential role for de novo NAPDH synthesis to empower TNBC progression into metastatic disease!

2023-02-23

Beautiful paper by Ana Gomes’ group showing a new connection between epigenetics and metabolism – Histone variant H3.3 dependent activation of NADK promoter leading to increased NADPH availability in tripled neg breast cancer

2023-02-24

Our st lab paper is out! Thanks to @lab_gomes for the opportunity to pull my weight in this project!

2023-02-23

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