Higher order assembly: folding the chromosome
- Sven A Sewitz, Zahra Fahmi, Karen Lipkow
- Curr Opin Struct Biol, 10.1016/j.sbi.2017.02.004
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
- Biola M Javierre, Oliver S Burren, Steven P Wilder, …, Chris Wallace, Mikhail Spivakov, Peter Fraser
- Cell, 10.1016/j.cell.2016.09.037
Systems Biology Approaches for Understanding Genome Architecture
- Sven Sewitz, Karen Lipkow
- Methods Mol Biol, 10.1007/978-1-4939-3631-1_9
An integrated model of transcription factor diffusion shows the importance of intersegmental transfer and quaternary protein structure for target site finding
- Hugo G Schmidt, Sven Sewitz, Steven S Andrews, Karen Lipkow
- PLoS One, 10.1371/journal.pone.0108575
Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
- Mallesham Bejugam, Mekala Gunaratnam, Sebastian Müller, …, Jonathan A Fletcher, Stephen Neidle, Shankar Balasubramanian
- None, 10.1021/ml100062z
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus
- Wanling Yang, Nan Shen, Dong-Qing Ye, …, Chak Sing Lau, Pak Chung Sham, Yu Lung Lau
- PLoS Genet, 10.1371/journal.pgen.1000841
Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
- Himesh Fernando, Sven Sewitz, Jeremy Darot, Simon Tavaré, Julian Leon Huppert, Shankar Balasubramanian
- Nucleic Acids Res, 10.1093/nar/gkp740
A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression
- Zoë A E Waller, Sven A Sewitz, Shang-Te Danny Hsu, Shankar Balasubramanian
- J Am Chem Soc, 10.1021/ja901892u
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression
- Mallesham Bejugam, Sven Sewitz, Pravin S Shirude, Raphaël Rodriguez, Ramla Shahid, Shankar Balasubramanian
- J Am Chem Soc, 10.1021/ja075881p
Functional coupling between the two active sites during Tn 10 transposition buffers the mutation of sequences critical for DNA hairpin processing
- Danxu Liu, Sven Sewitz, Paul Crellin, Ronald Chalmers
- Mol Microbiol, 10.1111/j.1365-2958.2006.05432.x
DNA looping and catalysis; the IHF-folded arm of Tn10 promotes conformational changes and hairpin resolution
- Paul Crellin, Sven Sewitz, Ronald Chalmers
- Mol Cell, 10.1016/s1097-2765(04)00052-8
The positive and negative regulation of Tn10 transposition by IHF is mediated by structurally asymmetric transposon arms
- Sven Sewitz, Paul Crellin, Ronald Chalmers
- Nucleic Acids Res, 10.1093/nar/gkg797