Academic lineage
- Frances H Arnold - Ph.D. student
Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454
- Tamas Benkovics, Feng Peng, Eric M Phillips, …, Tao Wang, Matthew S Winston, Feng Xu
- J Am Chem Soc, 10.1021/jacs.1c12106
A kinase-cGAS cascade to synthesize a therapeutic STING activator
- John A McIntosh, Zhijian Liu, Brian M Andresen, …, Guy R Humphrey, Kevin R Campos, Matthew L Maddess
- Nature, 10.1038/s41586-022-04422-9
Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19
- John A McIntosh, Tamas Benkovics, Steven M Silverman, …, Grant S Murphy, Kevin M Maloney, Patrick S Fier
- None, 10.1021/acscentsci.1c00608
Quantitation and speciation of residual protein within active pharmaceutical ingredients using image analysis with SDS-PAGE
- Joseph P Smith, Nicole M Ralbovsky, Mackenzie L Lauro, …, Ian Mangion, Narayan Variankaval, Xiaodong Bu
- J Pharm Biomed Anal, 10.1016/j.jpba.2021.114393
Deep Dive into Machine Learning Models for Protein Engineering
- Yuting Xu, Deeptak Verma, Robert P Sheridan, …, Edward C Sherer, Vladimir Svetnik, Jennifer M Johnston
- J Chem Inf Model, 10.1021/acs.jcim.0c00073
Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor
- Kari E Hernandez, Hans Renata, Russell D Lewis, …, David Rozzell, John A McIntosh, Frances H Arnold
- None, 10.1021/acscatal.6b02550
Molecular basis for the broad substrate selectivity of a peptide prenyltransferase
- Yue Hao, Elizabeth Pierce, Daniel Roe, …, Thomas E Cheatham, Eric W Schmidt, Satish K Nair
- Proc Natl Acad Sci U S A, 10.1073/pnas.1609869113
Metabolic model for diversity-generating biosynthesis
- Ma Diarey Tianero, Elizabeth Pierce, Shrinivasan Raghuraman, …, Baldomero M Olivera, Duane E Ruffner, Eric W Schmidt
- Proc Natl Acad Sci U S A, 10.1073/pnas.1525438113
Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450
- Christopher C Farwell, Ruijie K Zhang, John A McIntosh, Todd K Hyster, Frances H Arnold
- None, 10.1021/acscentsci.5b00056
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
- John A McIntosh, Thomas Heel, Andrew R Buller, Linda Chio, Frances H Arnold
- J Am Chem Soc, 10.1021/jacs.5b07107
Recognition sequences and substrate evolution in cyanobactin biosynthesis
- Debosmita Sardar, Elizabeth Pierce, John A McIntosh, Eric W Schmidt
- ACS Synth Biol, 10.1021/sb500019b