Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells
- Sushmita Chatterjee, Gonna Somu Naidu, Inbal Hazan-Halevy, …, David Sprinzak, Ronen Zaidel-Bar, Dan Peer
- Sci Adv, 10.1126/sciadv.ade4800
Precise alternating cellular pattern in the inner ear by coordinated hopping intercalations and delaminations
- Roie Cohen, Shahar Taiber, Olga Loza, …, Shahar Kasirer, Shiran Woland, David Sprinzak
- Sci Adv, 10.1126/sciadv.add2157
Structure of the planar cell polarity cadherins Fat4 and Dachsous1
- Elliot Medina, Yathreb Easa, Daniel K Lester, …, Eric K Lau, David Sprinzak, Vincent C Luca
- Nat Commun, 10.1038/s41467-023-36435-x
Notch signaling in development and homeostasis
- Oren Gozlan, David Sprinzak, Oren Gozlan, …, David Sprinzak, Oren Gozlan, David Sprinzak
- Development, 10.1242/dev.201138
Matrix stiffness regulates Notch signaling activity in endothelial cells
- Maibritt Kretschmer, Rose Mamistvalov, David Sprinzak, …, David Sprinzak, Angelika M Vollmar, Stefan Zahler
- J Cell Sci, 10.1242/jcs.260442
A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells
- Shahar Taiber, Oren Gozlan, Roie Cohen, …, Uri Manor, David Sprinzak, Karen B Avraham
- None, 10.3389/fcell.2022.974168
Functional Comparison between Endogenous and Synthetic Notch Systems
- Bassma Khamaisi, Vincent C Luca, Stephen C Blacklow, …, Vincent C Luca, Stephen C Blacklow, David Sprinzak
- ACS Synth Biol, 10.1021/acssynbio.2c00247
Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor
- Yi Kuang, Anna Pyo, Natanel Eafergan, …, Rhett A Kovall, David Sprinzak, Brian Gebelein
- PLoS Genet, 10.1371/journal.pgen.1009039
Mechanical forces shaping the development of the inner ear
- Roie Cohen, David Sprinzak
- Biophys J, 10.1016/j.bpj.2021.06.036
Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain
- Nicolas Dray, Laure Mancini, Udi Binshtok, …, Emmanuel Beaurepaire, David Sprinzak, Laure Bally-Cuif
- Cell Stem Cell, 10.1016/j.stem.2021.03.014
Biophysics of Notch Signaling
- David Sprinzak, Stephen C Blacklow
- Annu Rev Biophys, 10.1146/annurev-biophys-101920-082204
Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness
- Shahar Taiber, Roie Cohen, Ofer Yizhar-Barnea, David Sprinzak, Jeffrey R Holt, Karen B Avraham
- EMBO Mol Med, 10.15252/emmm.202013259
Roadmap for the multiscale coupling of biochemical and mechanical signals during development
- Pierre-François Lenne, Edwin Munro, Idse Heemskerk, …, Bassma Khamaisi, David Sprinzak, Sham Tlili
- Phys Biol, 10.1088/1478-3975/abd0db
Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear
- Roie Cohen, Liat Amir-Zilberstein, Micha Hersch, …, Sven Bergmann, Karen B Avraham, David Sprinzak
- Nat Commun, 10.1038/s41467-020-18894-8
Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism
- Yi Kuang, Ohad Golan, Kristina Preusse, …, Raphael Kopan, David Sprinzak, Brian Gebelein
- Elife, 10.7554/elife.53659