QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations
- Leonard R Pelgrom, Gavin M Davis, Simon O’Shaughnessy, …, Sander I Van Kasteren, David K Finlay, Linda V Sinclair
- Cell Rep, 10.1016/j.celrep.2023.112828
Canagliflozin impairs TÂ cell effector function via metabolic suppression in autoimmunity
- Benjamin J Jenkins, Julianna Blagih, Fernando M Ponce-Garcia, …, Linda V Sinclair, Emma E Vincent, Nicholas Jones
- Cell Metab, 10.1016/j.cmet.2023.05.001
The Immunological Proteome Resource
- Alejandro J Brenes, Angus I Lamond, Alejandro J Brenes, …, Alejandro J Brenes, Angus I Lamond, Doreen A Cantrell
- Nat Immunol, 10.1038/s41590-023-01483-4
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing
- Mariana P Cervantes-Silva, Richard G Carroll, Mieszko M Wilk, …, F Javier Sánchez-GarcÃa, Kingston H G Mills, Annie M Curtis
- Nat Commun, 10.1038/s41467-022-34897-z
Dendritic cells metabolism: a strategic path to improve antitumoral DC vaccination
- Emma Currivan, David Finlay, Diana Moreira, Emma Currivan, David Finlay, Diana Moreira
- Clin Exp Immunol, 10.1093/cei/uxac048
Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity
- Nidhi Kedia-Mehta, Laura Tobin, Vanessa Zaiatz-Bittencourt, …, Clair M Gardiner, David K Finlay, Andrew E Hogan
- Blood Adv, 10.1182/bloodadvances.2021005047
Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination
- Elena Woods, Vanessa Zaiatz-Bittencourt, Ciaran Bannan, …, Eleanor Barnes, Lucy Dorrell, Clair M Gardiner
- None, 10.1038/s41541-021-00381-w
Metabolic requirements of NK cells during the acute response against retroviral infection
- Elisabeth Littwitz-Salomon, Diana Moreira, Joe N Frost, …, Hal Drakesmith, Ulf Dittmer, David K Finlay
- Nat Commun, 10.1038/s41467-021-25715-z
Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy
- Chloe Choi, David K Finlay
- Stem Cell Res Ther, 10.1186/s13287-021-02377-8
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
- Jennifer K Dowling, Remsha Afzal, Linden J Gearing, …, Paul J Hertzog, Bryan R G Williams, Claire E McCoy
- Nat Commun, 10.1038/s41467-021-21617-2
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
- Nicholas Jones, Julianna Blagih, Fabio Zani, …, Karen H Vousden, Emma E Vincent, Catherine A Thornton
- Nat Commun, 10.1038/s41467-021-21461-4
De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells
- Katie L O’Brien, Nadine Assmann, Eimear O’Connor, …, Clair M Gardiner, Katja Dettmer, David K Finlay
- Eur J Immunol, 10.1002/eji.202048784
Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses
- Jessica F Walls, Jeff J Subleski, Erika M Palmieri, …, Clair M Gardiner, Daniel W McVicar, David K Finlay
- Elife, 10.7554/elife.59166
Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses
- Aisling O’Brien, Roisin M Loftus, Marta M Pisarska, …, David K Finlay, Donal O’Shea, Andrew E Hogan
- J Immunol, 10.4049/jimmunol.1801600