Scholar: David Christini

David Christini

A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells

  • Zaniar Ghazizadeh, Jiajun Zhu, Faranak Fattahi, …, Geoffrey S Pitt, Todd Evans, Shuibing Chen
  • None, 10.1016/j.isci.2022.104153
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Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia

  • Namit Gaur, Francis Ortega, Arie O Verkerk, …, David J Christini, Ruben Coronel, Edward J Vigmond
  • J Mol Cell Cardiol, 10.1016/j.yjmcc.2020.04.019
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Calibration of ionic and cellular cardiac electrophysiology models

  • Dominic G Whittaker, Michael Clerx, Chon Lok Lei, …, Chon Lok Lei, David J Christini, Gary R Mirams
  • None, 10.1002/wsbm.1482
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Light-Activated Dynamic Clamp Using iPSC-Derived Cardiomyocytes

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Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing

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Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes

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Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes

  • Kemar Brown, Stephanie Legros, Francis A Ortega, …, David J Christini, Richard B Robinson, Ann C Foley
  • PLoS One, 10.1371/journal.pone.0189818
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Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility

  • Ryan A Devenyi, Francis A Ortega, Willemijn Groenendaal, Trine Krogh-Madsen, David J Christini, Eric A Sobie
  • J Physiol, 10.1113/jp273191
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Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp

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