Scholar: Alejandro Chavez

Alejandro Chavez

Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases

  • George D Lampe, Rebeca T King, Tyler S Halpin-Healy, …, Stephen Tang, Alejandro Chavez, Samuel H Sternberg
  • None, 10.1101/2023.03.17.533036
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Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

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Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites

  • Sho Iketani, Seo Jung Hong, Jenny Sheng, …, Yosef Sabo, David D Ho, Alejandro Chavez
  • Cell Host Microbe, 10.1016/j.chom.2022.08.003
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The Functional Landscape of SARS-CoV-2 3CL Protease

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An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

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Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19

  • Hengrui Liu, Sho Iketani, Arie Zask, …, Alejandro Chavez, David D Ho, Brent R Stockwell
  • Nat Commun, 10.1038/s41467-022-29413-2
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Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity

  • Samuel J Resnick, Sho Iketani, Seo Jung Hong, …, Brent R Stockwell, David D Ho, Alejandro Chavez
  • J Virol, 10.1128/jvi.02374-20
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